MYC 和 PP2A 在髓性白血病发生和进展中的作用。
The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias.
机构信息
Medical Oncology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain.
出版信息
Cells. 2020 Feb 26;9(3):544. doi: 10.3390/cells9030544.
The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other's activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.
MYC 转录因子是最具特征的 PP2A 底物之一。MYC 癌基因的失调以及 PP2A 的失活是癌症中的两种常见事件。这两种蛋白都是细胞增殖、凋亡和分化的重要调节因子，它们直接和间接调节彼此的活性。癌症研究表明，针对 MYC/PP2A 网络是一种可行的临床策略。在这里，我们重点讨论和探讨了 MYC 和 PP2A 在髓系白血病中的作用。
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