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眼内抗血管内皮生长因子治疗对过敏性紫癜相关黄斑囊样水肿的影响——病例报告

Effect of intraocular anti-VEGF on cystoid macular edema associated with Henoch-Schonlein purpura-a case report.

作者信息

Pan Dongyan, Cui Xiao, Zhu Weiye, Qin Haifeng, Li Qing, Xu Bing, Wu Jin-Hui

机构信息

Department of Ophthalmology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Department of Ophthalmology, Third Hospital Affiliated to Second Military Medical University, Shanghai, China.

出版信息

BMC Ophthalmol. 2020 Feb 28;20(1):79. doi: 10.1186/s12886-020-01351-x.

DOI:10.1186/s12886-020-01351-x
PMID:32111177
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7049220/
Abstract

BACKGROUND

To report a bilateral cystoid macular edema associated with Henoch-Schonleinpurpura.

CASE PRESENTATION

A 21-year-old man presented a bilateral, painless, and bilateral blurred vision for 5 weeks with visual acuity (VA) of 6/12 on the right eye and 6/48 on the left. FA and OCT showed bilateral cystoid macular edema, and the fundus photograph showed retinal hemorrhages. Using intravenous dexamethasone could reduce macular edema, but it reoccurred shortly after switching to oral prednisone. Repeated intraocular injection of anti-VEGF in both eyes was performed and VA improved to 6/6 on the right eye and 6/7.5 on the left with the regression of edema after 6 months follow-up.

CONCLUSIONS

Intraocular anti-VEGF might be an alternative choice to glucocorticoid in cases of bilateral cystoid macular edema associated with Henoch-Schonlein purpura.

摘要

背景

报告1例与过敏性紫癜相关的双侧黄斑囊样水肿。

病例介绍

一名21岁男性，双侧无痛性视力模糊5周，右眼视力（VA）为6/12，左眼为6/48。荧光素眼底血管造影（FA）和光学相干断层扫描（OCT）显示双侧黄斑囊样水肿，眼底照片显示视网膜出血。静脉注射地塞米松可减轻黄斑水肿，但改用口服泼尼松后不久水肿复发。双眼反复眼内注射抗血管内皮生长因子（anti-VEGF），随访6个月后，右眼视力提高到6/6，左眼提高到6/7.5，水肿消退。

结论

对于与过敏性紫癜相关的双侧黄斑囊样水肿，眼内注射抗VEGF可能是糖皮质激素的替代选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/f22ba5765a3c/12886_2020_1351_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/af892943fa1a/12886_2020_1351_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/333fd088e0bd/12886_2020_1351_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/fb20da4e6ed7/12886_2020_1351_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/f22ba5765a3c/12886_2020_1351_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/af892943fa1a/12886_2020_1351_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/333fd088e0bd/12886_2020_1351_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/fb20da4e6ed7/12886_2020_1351_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a71/7049220/f22ba5765a3c/12886_2020_1351_Fig4_HTML.jpg

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