Department of Neuroinflammation and Brain Fatigue Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Department of Neuroinflammation and Brain Fatigue Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Neurosci Biobehav Rev. 2020 Mar;110:100-113. doi: 10.1016/j.neubiorev.2019.03.018.
Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate gene expression in a cell-specific manner. However, the literature reviews have indicated that glucose can also regulate gut cells to release incretins which might play a role in memory processes directly or indirectly by vagus nerve stimulation. In this review, we discussed the effects of glucose on the gut and brain, aiming to understand more in-depth the role of glucose in memory function. In addition, we also discussed the alteration of glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to Alzheimer's disease (AD) pathologies.
葡萄糖在能量代谢、食欲控制和记忆巩固等方面具有多种生理作用。我们最近报道称，与记忆相关的基因表达在小鼠脑细胞中受到表观遗传控制，并且葡萄糖可以以细胞特异性的方式调节基因表达。然而，文献综述表明，葡萄糖还可以调节肠道细胞释放肠促胰岛素，这些肠促胰岛素可能通过迷走神经刺激直接或间接地在记忆过程中发挥作用。在这篇综述中，我们讨论了葡萄糖对肠道和大脑的影响，旨在更深入地了解葡萄糖在记忆功能中的作用。此外，我们还讨论了 2 型糖尿病（T2DM）中葡萄糖信号的改变及其与阿尔茨海默病（AD）病理的可能联系。
