Hossain Md Shamim, Mawatari Shiro, Fujino Takehiko
Institute of Rheological Functions of Food, Fukuoka, Japan.
Front Cell Dev Biol. 2022 Feb 9;10:828282. doi: 10.3389/fcell.2022.828282. eCollection 2022.
Plasmalogens (Pls), a kind of glycerophospholipids, have shown potent biological effects but their role in hippocampus-dependent memory remained mostly elusive. Here, we first report Pls can enhance endogenous expression of brain-derived neurotrophic factor () in the hippocampus and promotes neurogenesis associated with improvement of learning and memory in mice. Genomic and proteomic studies revealed that Pls enhanced recruitment of CREB transcription factor onto the murine promoter region via upregulating ERK-Akt signaling pathways in neuronal cells. Reduction of endogenous Pls in murine hippocampus significantly reduced learning and memory associated with the reduction of memory-related protein expression, suggesting that Pls can regulate memory-related gene expression in the hippocampus.
缩醛磷脂（Pls）是一种甘油磷脂，已显示出强大的生物学效应，但其在海马体依赖性记忆中的作用大多仍不清楚。在此，我们首次报道缩醛磷脂可增强海马体中脑源性神经营养因子（BDNF）的内源性表达，并促进与小鼠学习和记忆改善相关的神经发生。基因组和蛋白质组学研究表明，缩醛磷脂通过上调神经元细胞中的ERK-Akt信号通路，增强了CREB转录因子在小鼠BDNF启动子区域的募集。小鼠海马体内源性缩醛磷脂的减少显著降低了学习和记忆能力，同时与记忆相关蛋白表达的减少有关，这表明缩醛磷脂可调节海马体中与记忆相关的基因表达。
