Serrao Alessandra, Lucani Benedetta, Assanto Manfredi Giovanni, Fiori Luciano, Baldacci Erminia, Aprile Simona Michela, Chistolini Antonio
"Sapienza", University of Rome, Via Benevento 6, 00161, Rome, Italy.
J Thromb Thrombolysis. 2020 Oct;50(3):718-723. doi: 10.1007/s11239-020-02070-2.
Anticoagulant therapy has undergone a significant change since direct oral anticoagulants (DOACs) introduction. Their obvious advantages including the fixed dose, the few interactions and less frequent controls, have made them the first choice anticoagulant therapy. More and more patients have therefore switched from therapy with vitamin K antagonists (VKAs) to DOACs. Aim of our study was to assess the satisfaction, quality of life (QoL) and therapy adherence of patients who switched from VKA to DOACs therapy. This single center study evaluated satisfaction and QoL of 107 patients who switched from VKA to DOACs therapy through Anti-Clot Treatment Scale and SF-36 respectively. The questionnaires were administered before therapy change, after 3 months of DOACs therapy and then annually. We also evaluated DOACs therapy adherence with a questionnaire administered each visit and through the measures of DOACs plasma levels. Patients' satisfaction and QoL were high during VKA therapy, but with DOACs we observed an improvement after the first 3 months and then maintained over the time of DOACs therapy. DOACs adherence was excellent, also confirmed by DOACs plasma levels.
自直接口服抗凝剂（DOACs）问世以来，抗凝治疗发生了重大变化。它们具有明显的优势，包括固定剂量、相互作用少且监测频率低，这使其成为抗凝治疗的首选。因此，越来越多的患者从维生素K拮抗剂（VKA）治疗转向DOACs治疗。我们研究的目的是评估从VKA转换为DOACs治疗的患者的满意度、生活质量（QoL）和治疗依从性。这项单中心研究分别通过抗凝治疗量表和SF-36评估了107例从VKA转换为DOACs治疗的患者的满意度和生活质量。问卷在治疗转换前、DOACs治疗3个月后以及之后每年进行一次。我们还通过每次就诊时发放的问卷以及DOACs血浆水平测量来评估DOACs治疗的依从性。在VKA治疗期间患者的满意度和生活质量较高，但在DOACs治疗中，我们观察到在最初3个月后有所改善，并且在DOACs治疗期间一直保持。DOACs的依从性很好，DOACs血浆水平也证实了这一点。
