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[青光眼凝胶支架植入致结膜穿孔后发生的眼内炎]

[Endophthalmitis after perforation of the conjunctiva by a glaucoma gel-stent implant].

作者信息

Moussaoui Laila El, Djalali-Talab Yassin, Walter Peter, Plange Niklas, Kuerten David, Fuest Matthias

机构信息

Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

出版信息

Ophthalmologe. 2020 Dec;117(12):1229-1233. doi: 10.1007/s00347-020-01077-7.

DOI:10.1007/s00347-020-01077-7
PMID:32112220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7717055/
Abstract

Intraocular infections associated with Abiotrophia defectiva are rare. This article reports the case of a 57-year-old woman with endophthalmitis associated with Abiotrophia defectiva 3 months after uncomplicated cataract surgery combined with the implantation of a glaucoma gel-stent in the right eye. The patient had complained of redness of the right upper nasal conjunctiva and pain for 2 weeks prior to the endophthalmitis. A topical steroid eyedrop treatment without antibiotic additives had temporarily improved the situation. The patient presented with hypopyon, acute deterioration of vision and severe periocular pain of the right eye since the early morning. The gel-stent had spontaneously perforated the conjunctiva. The patient was immediately started on local and systemic antibiotics and underwent pars plana vitrectomy with intravitreal antibiotic application 6 h after presentation. Unlike other ocular infections with Abiotrophia defectiva, this case had a relatively benign course most likely due to the prompt intervention. In clinical routine, patients, who present with acute deterioration of vision and pain after glaucoma surgery, should be examined urgently considering a possible spontaneous conjunctival perforation and late onset endophthalmitis. Additionally, conjunctivitis of unclear origin following ocular surgery should always be treated with antibiotics, particularly when steroids are administered and monitored closely.

摘要

与缺陷乏养菌相关的眼内感染较为罕见。本文报告了一例57岁女性患者,在右眼白内障手术联合植入青光眼凝胶支架且手术过程顺利3个月后,发生了与缺陷乏养菌相关的眼内炎。在发生眼内炎前2周,患者就已出现右上鼻侧结膜充血和疼痛症状。使用不含抗生素添加剂的局部类固醇眼药水治疗曾使病情暂时好转。自清晨起,患者右眼出现前房积脓、视力急剧下降和严重的眼周疼痛。凝胶支架已自行穿透结膜。患者就诊后6小时立即开始接受局部和全身抗生素治疗,并接受了玻璃体切除术及玻璃体内抗生素注射。与其他由缺陷乏养菌引起的眼部感染不同,该病例病程相对良性,这很可能是由于及时干预所致。在临床常规诊疗中,对于青光眼手术后出现视力急剧下降和疼痛的患者,应紧急检查,考虑是否存在结膜自发穿孔和迟发性眼内炎的可能。此外,眼部手术后病因不明的结膜炎应始终使用抗生素治疗,尤其是在使用类固醇药物时,并需密切监测。

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本文引用的文献

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Effect of the outer stent position on efficacy after minimally invasive transscleral glaucoma gel stent implantation.经巩膜微创青光眼凝胶支架植入术后外支架位置对疗效的影响。
Acta Ophthalmol. 2019 Dec;97(8):e1105-e1111. doi: 10.1111/aos.14167. Epub 2019 Jun 18.
2
Endophthalmitis After XEN Gel Stent Implantation: 2 Cases.XEN 凝胶支架植入术后眼内炎:2 例。
J Glaucoma. 2018 Dec;27(12):e191-e194. doi: 10.1097/IJG.0000000000001076.
3
Endophthalmitis Following XEN Stent Exposure.XEN 支架暴露后的眼内炎。
J Glaucoma. 2018 Oct;27(10):931-933. doi: 10.1097/IJG.0000000000001012.
4
Bacterial and Fungal Endophthalmitis.细菌性和真菌性眼内炎
Clin Microbiol Rev. 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16.
5
XEN Glaucoma Implant with Mitomycin C 1-Year Follow-Up: Result and Complications.含丝裂霉素C的XEN青光眼植入物1年随访:结果与并发症
J Ophthalmol. 2017;2017:5457246. doi: 10.1155/2017/5457246. Epub 2017 Mar 1.
6
Minimally invasive glaucoma surgery: current status and future prospects.微创青光眼手术:现状与未来展望。
Clin Ophthalmol. 2016 Jan 28;10:189-206. doi: 10.2147/OPTH.S80490. eCollection 2016.
7
Outcomes and bleb-related complications of trabeculectomy.小梁切除术的结果和滤过泡相关并发症。
Ophthalmology. 2012 Apr;119(4):712-22. doi: 10.1016/j.ophtha.2011.09.049. Epub 2012 Jan 14.
8
Abiotrophia defectiva endophthalmitis with retinal involvement and infiltrative keratitis: case report and review of the literature.缺陷拟杆菌相关性眼内炎伴视网膜累及和浸润性角膜炎:病例报告及文献复习。
Eur J Clin Microbiol Infect Dis. 2010 Jun;29(6):727-31. doi: 10.1007/s10096-010-0901-7. Epub 2010 Apr 22.
9
Granulicatella adiacens and Abiotrophia defectiva bacteraemia characterized by 16S rRNA gene sequencing.以16S rRNA基因测序为特征的毗邻颗粒链菌和营养缺陷菌血症
J Med Microbiol. 2003 Feb;52(Pt 2):137-140. doi: 10.1099/jmm.0.04950-0.
10
Abiotrophia species as a cause of endophthalmitis following cataract extraction.营养缺陷菌属作为白内障摘除术后眼内炎的一个病因
J Clin Microbiol. 1999 May;37(5):1564-6. doi: 10.1128/JCM.37.5.1564-1566.1999.