Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Ave, No, Wuhan, 1095, China.
Support Care Cancer. 2020 Nov;28(11):5299-5306. doi: 10.1007/s00520-020-05333-z. Epub 2020 Feb 28.
Adjuvant chemotherapy is recommended for patients with curatively resected colorectal cancer. The aim of this study is to evaluate the impact of unmet supportive care needs and anxiety on the initiation of postoperative adjuvant chemotherapy in colorectal cancer patients.
This is a retrospective study from a single tertiary referral hospital. Patients diagnosed with colorectal cancer who met the inclusion criteria were included. The Hospital Anxiety and Depression Scale (HADS) and modified 34-item Supportive Care Needs Survey (SCNS-SF34) were applied to assess patient's anxiety level and unmet needs. The time intervals between initiation of adjuvant chemotherapy and operation were recorded. Factors associated with delayed initiation of chemotherapy were investigated in univariate and multivariate analysis.
A total of 135 patients with colorectal cancer were included. In total, 16.3% (22/135) and 5.2% (7/135) reported symptoms of anxiety and depression. In multivariate analysis, low to moderate income status, postoperative complications, anxiety, and high level of unmet needs are independent risk factors for late initiation of chemotherapy.
Our findings showed that psychological problems such as anxiety and high unmet supportive needs are correlated with delayed initiation of adjuvant chemotherapy in colorectal cancer patients.
辅助化疗被推荐用于可治愈性切除的结直肠癌患者。本研究旨在评估未满足的支持性护理需求和焦虑对结直肠癌患者术后辅助化疗启动的影响。
这是一项来自一家三级转诊医院的回顾性研究。纳入符合纳入标准的结直肠癌患者。采用医院焦虑抑郁量表（HADS）和改良的 34 项支持性护理需求调查（SCNS-SF34）评估患者的焦虑水平和未满足的需求。记录辅助化疗开始与手术之间的时间间隔。在单因素和多因素分析中探讨与化疗启动延迟相关的因素。
共纳入 135 例结直肠癌患者。共有 16.3%（22/135）和 5.2%（7/135）的患者报告有焦虑和抑郁症状。多因素分析显示，中低收入状态、术后并发症、焦虑和高度未满足的需求是化疗启动延迟的独立危险因素。
我们的研究结果表明，焦虑等心理问题和较高的未满足支持性需求与结直肠癌患者辅助化疗启动延迟有关。
