上转换荧光纳米探针用于高灵敏度的活体细胞示踪。

Upconversion Fluorescent Nanoprobe for Highly Sensitive In Vivo Cell Tracking.

机构信息

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, China.

出版信息

Methods Mol Biol. 2020;2126:85-93. doi: 10.1007/978-1-0716-0364-2_8.

DOI:10.1007/978-1-0716-0364-2_8

PMID:32112381

Abstract

Near-infrared (NIR)-to-visible upconversion nanomaterials (UCNPs) used as biomedical nanoprobes have considerable advantages over the traditional used "downconversion" fluorescent dyes. Functionalized upconversion nanoparticles (UCNPs) represent high sensitivity and great biocompatibility. Cells labeled with these UCNPs can be tracked for long term in vivo. Here we describe UCNP-PEG-ARG for highly sensitive in vivo cell tracking.

摘要

近红外（NIR）-可见上转换纳米材料（UCNPs）作为生物医学纳米探针的应用具有传统“下转换”荧光染料无法比拟的优势。功能化上转换纳米颗粒（UCNPs）具有高灵敏度和良好的生物相容性。用这些 UCNPs 标记的细胞可以在体内进行长期跟踪。在这里，我们描述了 UCNP-PEG-ARG 用于高灵敏度的体内细胞跟踪。