分析 2243 例抗胃壁细胞抗体阳性患者的临床特征。
Analysis of clinical characteristics of 2243 with positive anti-gastric parietal cell antibody.
机构信息
Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, China.
Department of Gastroenterology, Baoding NO.1 Central Hospital, Baoding, China.
出版信息
J Clin Lab Anal. 2020 Jul;34(7):e23264. doi: 10.1002/jcla.23264. Epub 2020 Feb 28.
BACKGROUND
To facilitate the early detection of chronic diseases, we analyzed the clinical characteristics of anti-gastric parietal cell antibody (PCA)-positive population, revealed the early characteristics of the population.
METHODS
According to the retrospective analysis, current situation investigation and comparative analysis of the clinical characteristics and medical history of the subjects, the comparison between the groups was performed.
RESULT
(a) The positive rate of PCA detection in department of gastroenterology in our hospital was 35.80%. Among the individuals who underwent PCA, esophagogastroduodenoscopy (EGD) and pathological examination at the same time, 33.59% of the patients with PCA positive were diagnosed as atrophic gastritis by gastroscopy, which was much higher than 9.09% of the patients with PCA negative. (b) The incidence of gastroesophageal reflux, hypertension, ischemic heart disease (IHD) and cerebral ischemia in PCA-positive population were 65.45%, 81.63%, 15.43%, and 31.61%, respectively, which were significantly higher than those in the control group. (c) The incidence rates of decreased red blood cells (RBC) and increased homocysteine (HCY) in laboratory-related tests were 38.30% and 69.15%, respectively, which were much higher than those in control group.
CONCLUSION
PCA has predictive value for a variety of chronic diseases and timely detection is of great significance.
背景
为了促进慢性病的早期发现，我们分析了抗胃壁细胞抗体（PCA）阳性人群的临床特征，揭示了该人群的早期特征。
方法
通过回顾性分析、现状调查和对受试者临床特征和病史的对比分析，对各组进行比较。
结果
（a）我院消化内科 PCA 检测阳性率为 35.80%。在同时进行 PCA 和食管胃十二指肠镜（EGD）及病理检查的人群中，33.59%的 PCA 阳性患者经胃镜诊断为萎缩性胃炎，明显高于 PCA 阴性患者的 9.09%。（b）PCA 阳性人群中胃食管反流、高血压、缺血性心脏病（IHD）和脑缺血的发生率分别为 65.45%、81.63%、15.43%和 31.61%，明显高于对照组。（c）实验室相关检查中红细胞（RBC）减少和同型半胱氨酸（HCY）升高的发生率分别为 38.30%和 69.15%，明显高于对照组。
结论
PCA 对多种慢性疾病具有预测价值，及时检测具有重要意义。
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