Departments of, Department of, Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Department of, Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Diabet Med. 2020 Jun;37(6):1058-1065. doi: 10.1111/dme.14283. Epub 2020 Mar 20.
To evaluate the burden and association of cardiometabolic risk factors in the spouses of women with and without hyperglycaemia in pregnancy.
Women with (n = 204) and without (n = 197) hyperglycaemia in pregnancy, along with their spouses, participated in this cross-sectional study. The hyperglycaemia in pregnancy group included women with gestational diabetes and diabetes in pregnancy. A detailed questionnaire was completed for all participants (men and women), documenting relevant personal and medical history, along with biochemical investigations (men).
A total of 401 couples were evaluated at the time point during the pregnancy of 24.7 ± 5.2 gestational weeks (mean ± sd). Dysglycaemia (prediabetes or diabetes), overweight/obesity (BMI ≥25 kg/m ) and metabolic syndrome were detected in 120 (58.9%), 123 (60.3%) and 98 spouses (48.3%) of women with hyperglycaemia in pregnancy, respectively. In the fully adjusted model, an increased risk of dysglycaemia [odds ratio 1.43 (95% CI 0.95-2.17); P = 0.088], overweight/obesity [odds ratio 1.49 (95% CI 0.98-2.27); P = 0.064] and metabolic syndrome [odds ratio 2.00 (95% CI 1.30-3.07); P = 0.001] was seen in the spouses of women with hyperglycaemia in pregnancy. The prevalence of these metabolic conditions was higher in spouses of women with diabetes in pregnancy compared to spouses of women with gestational diabetes mellitus.
A high burden of cardiometabolic risk factors was observed in the spouses of women with hyperglycaemia in pregnancy. The opportunity provided by pregnancy could be used by the healthcare system not only to improve the health of the woman and her offspring, but also her spouse.
评估妊娠合并和不合并高血糖的女性配偶的心血管代谢危险因素负担及其相关性。
本横断面研究纳入了 204 名妊娠合并高血糖的女性（高血糖组）和 197 名妊娠不合并高血糖的女性（对照组）及其配偶。高血糖组包括妊娠期糖尿病和糖尿病合并妊娠的女性。所有参与者（男性和女性）均完成了详细的问卷，记录了相关的个人和医疗史，以及生化检查（男性）。
在妊娠 24.7±5.2 周（均值±标准差）时，共评估了 401 对夫妇。高血糖组女性的配偶中，分别有 120 名（58.9%）、123 名（60.3%）和 98 名（48.3%）存在糖代谢异常（糖尿病前期或糖尿病）、超重/肥胖（BMI≥25kg/m ）和代谢综合征。在完全调整的模型中，高血糖组女性的配偶发生糖代谢异常的风险增加[比值比（OR）1.43（95%可信区间 0.95-2.17）；P=0.088]、超重/肥胖（OR 1.49（95%可信区间 0.98-2.27）；P=0.064）和代谢综合征（OR 2.00（95%可信区间 1.30-3.07）；P=0.001）的风险增加。与妊娠合并妊娠期糖尿病的女性的配偶相比，妊娠合并糖尿病的女性的配偶更易发生这些代谢异常。
妊娠合并高血糖的女性的配偶存在较高的心血管代谢危险因素负担。医疗保健系统不仅可以利用妊娠的机会来改善女性及其后代的健康，还可以改善其配偶的健康。
