Division for Infection Control and Environmental Health, Department of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
Zoonoses Public Health. 2020 Jun;67(4):370-381. doi: 10.1111/zph.12696. Epub 2020 Feb 29.
The tick-borne encephalitis virus (TBEV), a zoonotic flaviviral infection, is endemic in large parts of Norway and Eurasia. Humans are mainly infected with TBEV via bites from infected ticks. In Norway, the main geographical distribution of ticks is along the Norwegian coastline from southeast (59°N) and up to the southern parts of Nordland County (65°N). In this study, we collected ticks by flagging along the coast from Østfold County to Nordland County. By whole-genome sequencing of the mitochondrial genome of Ixodes ricinus, the phylogenetic tree suggests that there is limited phylogeographic structure both in Norway and in Europe. The overall TBEV prevalence is 0.3% for nymphs and 4.3% for adults. The highest estimated TBEV prevalence in adult ticks was detected in Rogaland and Vestfold County, while for nymphs it is highest in Vestfold, Vest-Agder and Rogaland. The present work is one of the largest studies on distribution and prevalence of TBEV in ticks in Scandinavia, showing that the virus is wider distributed in Norway than previously anticipated.
蜱传脑炎病毒（TBEV）是一种人畜共患的黄病毒感染，在挪威和欧亚大陆的大部分地区流行。人类主要通过感染蜱的叮咬感染 TBEV。在挪威，蜱的主要地理分布是沿着挪威海岸线从东南部（约 59°N）到诺德兰县的南部（约 65°N）。在这项研究中，我们沿着从奥斯特福德县到诺德兰县的海岸线用旗帜采集了蜱。通过对 Ixodes ricinus 的线粒体基因组进行全基因组测序，系统发育树表明挪威和欧洲的蜱传脑炎病毒的系统地理学结构有限。若以若以幼虫为检测对象，TBEV 的总体流行率为 0.3%；若以成蜱为检测对象，TBEV 的总体流行率为 4.3%。在成人蜱中，罗加兰和维斯特福德县的 TBEV 流行率最高，而在幼虫中，流行率最高的是维斯特福尔德、西峡湾和罗加兰。本研究是斯堪的纳维亚地区关于蜱传脑炎病毒分布和流行率的最大研究之一，表明该病毒在挪威的分布比以前预期的更为广泛。
