Second Department of Neurology, the 4(th) Hospital of Daqing, Heilongjiang, 163000, No. 198, Central Street, Ranghulu District, Daqing City, China.
Second Department of Neurology, the 4(th) Hospital of Daqing, Heilongjiang, 163000, No. 198, Central Street, Ranghulu District, Daqing City, China.
Neurosci Lett. 2020 Apr 23;725:134873. doi: 10.1016/j.neulet.2020.134873. Epub 2020 Feb 26.
Blood levels of progranulin (PGRN) are suggested to be decreased in patients with Parkinson's disease (PD). However, the association between blood levels of progranulin and the severity of PD is not yet clear. A total of 55 PD patients and 55 normal control (NC) subjects were recruited in the present study. Hoehn and Yahr stages (H&Y) and Unified Parkinson's Disease Rating Scale scores (UPDRS) were examined to assess the severity of the disease. UPDRS motor section (UPDRS-III) was used to assess the motor function of the patients. Plasma levels of PGRN were tested by Elisa assays. Plasma PGRN levels are significantly decreased in PD patients (PD vs. NC: 333.8 ± 8.067 vs. 364.2 ± 10.11 ng/ml, p = 0.020). In the subgroup analysis, plasma PGRN levels decrease as H&Y score increases (H&Y = 1 vs. H&Y = 2: 363.5 ± 3.251 vs. 336.3 ± 7.403 ng/ml, p = 0.013; H&Y = 1 vs. H&Y = 3-5: 363.5 ± 3.251 vs. 218.1 ± 18.12 ng/ml, p < 0.001; H&Y = 2 vs. H&Y = 3-5: 336.3 ± 7.403 vs. 218.1 ± 18.12 ng/ml, p = 0.076). Plasma levels of progranulin are negatively correlated with the severity of PD, as reflected by UPDRS (γ=-0.754, p < 0.001), UPDRS-III (γ=-0.808, p < 0.001) and disease duration (γ=-0.633, p < 0.001). Circulating PGRN levels might be a potential indicator of the disease severity of PD.
研究表明，帕金森病（PD）患者的颗粒蛋白前体（PGRN）水平降低。然而，PGRN 水平与 PD 严重程度之间的关系尚不清楚。本研究共招募了 55 例 PD 患者和 55 例正常对照（NC）受试者。采用 Hoehn 和 Yahr 分期（H&Y）和统一帕金森病评定量表评分（UPDRS）评估疾病严重程度。采用 UPDRS 运动评分（UPDRS-III）评估患者的运动功能。通过 ELISA 检测血浆 PGRN 水平。PD 患者的血浆 PGRN 水平显著降低（PD 组与 NC 组：333.8±8.067 与 364.2±10.11ng/ml，p=0.020）。亚组分析显示，随着 H&Y 评分的增加，血浆 PGRN 水平降低（H&Y=1 与 H&Y=2：363.5±3.251 与 336.3±7.403ng/ml，p=0.013；H&Y=1 与 H&Y=3-5：363.5±3.251 与 218.1±18.12ng/ml，p<0.001；H&Y=2 与 H&Y=3-5：336.3±7.403 与 218.1±18.12ng/ml，p=0.076）。PGRN 血浆水平与 PD 严重程度呈负相关，反映在 UPDRS（γ=-0.754，p<0.001）、UPDRS-III（γ=-0.808，p<0.001）和疾病持续时间（γ=-0.633，p<0.001）上。循环 PGRN 水平可能是 PD 疾病严重程度的潜在指标。
