Yin Guangwen, Zhang Yidan, Geng Mengmeng, Cai Bingjie, Zheng Yunpeng
The First Affiliated Hospital of Zhengzhou University, China.
The First Affiliated Hospital of Zhengzhou University, China.
Photodiagnosis Photodyn Ther. 2020 Jun;30:101658. doi: 10.1016/j.pdpdt.2020.101658. Epub 2020 Feb 26.
Condyloma acuminata are a type of verrucous hyperplasia in the genital and perianal areas caused by human papilloma virus (HPV) infection. Traditional treatment methods for condyloma acuminata, such as topical medications, carbon dioxide (CO) laser, cryotherapy, and surgical excision, can be effective at removing warts, however, they do not eliminate subclinical and latent HPV infection, resulting in a high recurrence rate and even leaving trauma and scars. We report a case of condyloma acuminata covering the glans penis, considering our patient had a singular, large lesion, thus, to reduce the risk of recurrence and minimize the trauma caused by treatment, we chose ALA/photodynamic therapy (ALA-PDT). We provided eight rounds of ALA-PDT at a treatment interval of 7 days, the skin lesion disappeared completely, leaving a chapped, flushed glans without scarring. There was no recurrence during the 6-month follow-up period. Thus, we firmly believe that ALA-PDT is an effective, safe, and curative treatment, and is worth popularizing in clinical practice.
尖锐湿疣是由人乳头瘤病毒（HPV）感染引起的生殖器和肛周区域的一种疣状增生。尖锐湿疣的传统治疗方法，如外用药物、二氧化碳（CO）激光、冷冻疗法和手术切除，在去除疣体方面可能有效，然而，它们并不能消除亚临床和潜伏的HPV感染，导致复发率高，甚至会留下创伤和疤痕。我们报告一例覆盖阴茎头的尖锐湿疣病例，考虑到我们的患者有一个单一的大病灶，因此，为了降低复发风险并将治疗引起的创伤降至最低，我们选择了氨基酮戊酸/光动力疗法（ALA-PDT）。我们以7天的治疗间隔进行了八轮ALA-PDT，皮肤病变完全消失，阴茎头出现皲裂、潮红，无疤痕形成。在6个月的随访期内无复发。因此，我们坚信ALA-PDT是一种有效、安全且可治愈的治疗方法，值得在临床实践中推广。
