The First Affiliated Hospital of Zhengzhou University, No.1 East Road, Zheng Zhou, Henan, China.
The First Affiliated Hospital of Zhengzhou University, No.1 East Road, Zheng Zhou, Henan, China.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102746. doi: 10.1016/j.pdpdt.2022.102746. Epub 2022 Feb 2.
Condyloma acuminatum is a benign proliferative lesion of the genitalia and perianal region caused by human papillomavirus infection, which is rare in children. Traditional treatments include topical medications, CO laser therapy, cryotherapy, and surgical resection, which are often associated with pain, scarring, and recurrence. In recent years, aminolevulinic acid/photodynamic therapy has been applied as a new method for treating condyloma acuminatum in adults. However, its application in young children is limited. We herein report a case of condyloma acuminatum treated by aminolevulinic acid/photodynamic therapy in a young boy.
The patient was a 2-year-old boy who presented with a 10-day history of warty masses on his glans penis. Condyloma acuminatum was diagnosed based on skin lesions and histological findings. Aminolevulinic acid/photodynamic therapy was selected as the treatment method after obtaining informed consent from his guardians. We performed five rounds with a treatment interval of 7 days and achieved a complete disappearance of the skin lesions without chapping, flushing, or scarring. There was no recurrence during the 6-month follow-up period.
Photodynamic therapy can be used as an alternative treatment for condyloma acuminatum in young children. More case studies are needed to confirm the value of this treatment.
尖锐湿疣是一种由人乳头瘤病毒感染引起的生殖器和肛周良性增生性病变，在儿童中较为罕见。传统的治疗方法包括局部药物治疗、CO2 激光治疗、冷冻治疗和手术切除等，但这些方法往往伴随着疼痛、瘢痕和复发等问题。近年来，氨基酮戊酸/光动力疗法已被应用于成人尖锐湿疣的治疗，但在儿童中的应用有限。我们在此报告一例 2 岁男孩采用氨基酮戊酸/光动力疗法治疗尖锐湿疣的病例。
患儿因龟头赘生物就诊，病程 10 天。根据皮损和组织病理学检查，诊断为尖锐湿疣。在获得患儿监护人知情同意后，选择氨基酮戊酸/光动力疗法进行治疗。共进行了 5 个疗程，治疗间隔为 7 天，皮损完全消退，未见皲裂、潮红或瘢痕。随访 6 个月无复发。
光动力疗法可作为儿童尖锐湿疣的一种替代治疗方法。需要更多的病例研究来证实这种治疗方法的价值。
