Biotechnology and Medical Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran; Department of Environmental Health Engineering, School of Public Health, Ilam University of Medical Sciences, Ilam, Iran.
Centro de Investigación en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca, Morelos, 62210, Mexico.
Environ Res. 2020 May;184:109263. doi: 10.1016/j.envres.2020.109263. Epub 2020 Feb 20.
Environmental exposure to nonylphenol (NP) can adversely affect human and wildlife health. A systematic review was conducted to evaluate the relationship between environmental NP exposure and cancer progression risk. Literature surveys were conducted within several international databases using appropriate keywords. A comprehensive search yielded 58 eligible studies involving a wide range of adverse effects, exposure assessment methods, study designs, and experimental models. Most studies reported that NP strongly induced breast cancer progression in intended experiments. Positive associations between NP exposure and ovarian, uterine, pituitary, and testicular cancers were also reported. Although some studies reported no relation between environmental NP exposure and tumour and/or cancer progression, NP (a known endocrine disrupting chemical) induced action mechanisms in multiple experimental models and may interfere with/hyper-activate oestrogen signalling. Secretion of oestrogen and development of reproductive tissues like breasts, uteruses, and ovaries showed strong associations with possible neoplasia (i.e., uncontrolled development of tumours and/or malignant cancers). Findings of this study are important for informing policymakers to pass legislation limiting the use of environmental contaminants such as NP before all adverse effects of exposure have been determined.
环境暴露于壬基酚（NP）会对人类和野生动物的健康产生不利影响。本研究旨在评估环境 NP 暴露与癌症进展风险之间的关系，为此进行了系统评价。使用适当的关键词在多个国际数据库中进行了文献检索。全面搜索共获得 58 项符合条件的研究，这些研究涉及广泛的不良影响、暴露评估方法、研究设计和实验模型。大多数研究报告称，NP 在预期实验中强烈诱导乳腺癌进展。此外，NP 暴露与卵巢癌、子宫癌、垂体癌和睾丸癌之间也存在正相关关系。尽管一些研究报告称环境 NP 暴露与肿瘤和/或癌症进展之间没有关系，但 NP（一种已知的内分泌干扰化学物质）在多种实验模型中诱导的作用机制可能会干扰/过度激活雌激素信号。雌激素的分泌和乳房、子宫和卵巢等生殖组织的发育与可能的肿瘤形成（即肿瘤和/或恶性癌症的不受控制的发展）密切相关。本研究的结果对于告知决策者在确定暴露的所有不良影响之前通过立法限制 NP 等环境污染物的使用非常重要。
