Department of Dermatology, University of California, Irvine, CA 92697, USA.
Department of Molecular Pharmacology, Kitasato University School of Pharmacy, Tokyo 108-8641, Japan.
Int Immunopharmacol. 2020 Apr;81:106289. doi: 10.1016/j.intimp.2020.106289. Epub 2020 Feb 26.
The "5 International Symposium on Non-neuronal Acetylcholine: from bench to bedside" was held on September 27-29, 2019 in Hyatt Regency, Long Beach, CA, USA. Approximately 50 scientists from 11 countries over 6 continents participated in this meeting. The major topics included an overall biologic significance of non-neuronal acetylcholine (ACh) and the roles of the non-neuronal cholinergic systems in mucocutaneous, respiratory, digestive, immunologic, endocrine, cardiovascular, musculoskeletal and kidney diseases, and cancer. This meeting facilitated continued work to advance the fundamental science and translational aspects of the interdisciplinary studies on non-neuronal ACh. The progress made has opened a new chapter in the field of cholinergic pharmacology, and advanced our knowledge beyond regulation of individual cell- and tissue-types, defining a new paradigm of selective pharmacological regulation of vital function of practically all types of non-neuronal cells. It is now clear that the autocrine and paracrine control of non-neuronal cells by non-neuronal ACh is implemented through synergistic, additive, and reciprocal effects triggered by two different cholinergic receptor classes. Each biologic effect of ACh is determined by a unique combination of cholinergic receptors subtype expressed at each stage of cell development and differentiation. The plasticity of the non-neuronal cholinergic system helps adjust homeostasis to new environmental conditions.
“第五届非神经乙酰胆碱国际研讨会：从基础到临床”于 2019 年 9 月 27 日至 29 日在美国加利福尼亚州长滩凯悦酒店举行。来自六大洲 11 个国家的约 50 名科学家参加了此次会议。主要议题包括非神经乙酰胆碱（ACh）的总体生物学意义，以及非神经胆碱能系统在黏膜皮肤、呼吸、消化、免疫、内分泌、心血管、肌肉骨骼和肾脏疾病以及癌症中的作用。此次会议促进了非神经 ACh 跨学科研究的基础科学和转化方面的持续工作。所取得的进展为胆碱能药理学领域开辟了一个新篇章，将我们的知识从单个细胞和组织类型的调控扩展到了所有类型的非神经细胞的重要功能的选择性药理学调控，定义了一个新的范式。现在很明显，非神经 ACh 对非神经细胞的自分泌和旁分泌控制是通过两种不同的胆碱能受体类别的协同、累加和相互作用来实现的。ACh 的每一种生物学效应都是由在细胞发育和分化的每个阶段表达的独特的胆碱能受体亚型组合决定的。非神经胆碱能系统的可塑性有助于使内稳态适应新的环境条件。
