Zhang Jiwei, Wei Liting, Chen Dingbang, Feng Li, Wu Chao, Wang Rui, Li Xunhua, Liu Hongbo
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China.
Department of Neurology, Luoyang Central Hospital affiliated to Zhengzhou University, Luoyang, Henan 467500, China.
Stem Cell Res. 2020 Apr;44:101741. doi: 10.1016/j.scr.2020.101741. Epub 2020 Feb 20.
Human IPSC Line, ZZUNEUi004-A, was generated from a 34-year-old male patient with Wilson's Disease carrying a homozygous Pro992Leu mutation in ATP7B gene, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype.
人诱导多能干细胞系ZZUNEUi004-A由一名34岁患有威尔逊氏病的男性患者的细胞生成，该患者的ATP7B基因携带纯合Pro992Leu突变，采用非整合重编程方法。该细胞系在体外和体内均表现出多能性，且具有正常的核型。
