Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Colloids Surf B Biointerfaces. 2020 Jun;190:110891. doi: 10.1016/j.colsurfb.2020.110891. Epub 2020 Feb 21.
Osteosarcoma is one of the most common malignant bone tumors which affect adolescents. Neoadjuvant chemotherapy followed by operation has become recommended for osteosarcoma treatment. Whereas, the effects of conventional chemotherapy are unsatisfactory because of multidrug resistance, fast clearance rate, nontargeted delivery, side effects and so on. Accordingly, Nanoparticle-mediated targeted drug delivery system (NTDDS) is recommended to be a novel treatment strategy for osteosarcoma. NTDDS can overcome the above obstacles by enhanced permeability and retention effect and active targeting. The active targeting of the delivery system is mainly based on ligands. In this study, we investigate and summarize the most common ligands used in the latest NTDDS for osteosarcoma. It might provide new insights into nanomedicine for osteosarcoma treatment.
骨肉瘤是一种常见的青少年恶性骨肿瘤。新辅助化疗后再手术已成为骨肉瘤治疗的推荐方法。然而，由于多药耐药、清除率快、非靶向递送、副作用等原因，传统化疗的效果并不理想。因此，纳米颗粒介导的靶向药物递送系统（NTDDS）被推荐为骨肉瘤的一种新的治疗策略。NTDDS 可以通过增强的通透性和保留效应以及主动靶向来克服上述障碍。该递送系统的主动靶向主要基于配体。在本研究中，我们调查和总结了最新 NTDDS 中用于骨肉瘤的最常见配体。这可能为骨肉瘤的纳米医学治疗提供新的思路。
