Roddie M E, Peters A M, Osman S, Danpure H J, Lavender J P, Neirinckx R D
Department of Nuclear Medicine, Hammersmith Hospital, London, UK.
Nucl Med Commun. 1988 Oct;9(10):713-7. doi: 10.1097/00006231-198810000-00007.
The use of 111In-labelled granulocyte scintigraphy is recognized as a reliable method for detecting osteomyelitis and has similar sensitivity and significantly increased specificity compared to bone scintigraphy and 67Ga studies. Recent published work using pure granulocytes labelled with 111In tropolonate to detect osteomyelitis resulted in sensitivity of 100% and specificity of 92%. 99Tcm as an alternative granulocyte label offers advantages of convenience, lower radiation dose and higher image resolution. We have scanned 20 patients with suspected osteomyelitis using autologous granulocytes labelled with 99Tcm hexamethylpropyleneamineoxime (HMPAO), 12 of whom had prosthetic joints. The scan results were correlated with clinical, radiographic, microbiological and histological findings. Sensitivity was 100% and specificity was 93% which compares favourably with results obtained using 111In-labelled granulocytes. We believe that labelled granulocyte scintigraphy is a useful investigation in the diagnosis of osteomyelitis and that 99Tcm HMPAO appears to be at least as useful as 111In as the labelling agent.
铟 - 111标记的粒细胞闪烁扫描术被认为是检测骨髓炎的可靠方法，与骨闪烁扫描术和镓 - 67研究相比，其具有相似的敏感性且特异性显著提高。最近发表的使用铟 - 111托酚酮标记的纯粒细胞检测骨髓炎的研究，敏感性达100%，特异性为92%。锝 - 99作为粒细胞标记物的替代物，具有方便、辐射剂量低和图像分辨率高的优点。我们使用锝 - 99六甲基丙烯胺肟（HMPAO）标记的自体粒细胞对20例疑似骨髓炎患者进行了扫描，其中12例患者有假体关节。扫描结果与临床、放射学、微生物学和组织学检查结果相关。敏感性为100%，特异性为93%，与使用铟 - 111标记粒细胞获得的结果相比具有优势。我们认为标记粒细胞闪烁扫描术在骨髓炎诊断中是一种有用的检查方法，并且锝 - 99 HMPAO作为标记剂似乎至少与铟 - 111一样有用。
