Spencer R P, Mukherji B
Department of Nuclear Medicine, University of Connecticut Health Center, Farmington 06032.
Nucl Med Commun. 1988 Oct;9(10):783-6. doi: 10.1097/00006231-198810000-00016.
Upon coculture of peripheral blood lymphocytes (PBL) in the presence of irradiated autologous tumour cells, the PBL can be sensitized to the tumour (or perhaps more correctly resensitized), as shown by in vitro cytotoxic properties. The cells can be proliferated in the presence of interleukin-2, radiolabelled with 111In and injected back into the cell donor. Using this technique, tumour deposits were localized in five out of seven patients. Possible techniques for increasing the specificity of this form of adoptive immunocytotherapy are pointed out.
在外周血淋巴细胞（PBL）与经照射的自体肿瘤细胞共培养时，PBL可对肿瘤产生致敏作用（或许更准确地说是再次致敏），这已通过体外细胞毒性特性得到证实。这些细胞可在白细胞介素-2存在的情况下增殖，用铟-111进行放射性标记后再回输到细胞供体体内。利用该技术，7例患者中有5例的肿瘤沉积物被定位。文中指出了提高这种过继性免疫细胞治疗形式特异性的可能技术。
