Fei X, Sheng Z Y, Yao Y M
Trauma Research Center, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
Zhonghua Shao Shang Za Zhi. 2020 Feb 20;36(2):150-155. doi: 10.3760/cma.j.issn.1009-2587.2020.02.014.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Further development of sepsis usually leads to septic shock or even death. Many previous studies have focused on the abnormal reactions of monocytes/macrophages, neutrophils, complement system, or cytokine inflammation in sepsis. Many evidences in recent years suggest that dendritic cells, as the most powerful antigen-presenting cells in innate immune system of body, play important role during the process of immune disorders of sepsis. In this article, I review the main classification, immune function, monitoring method, regulatory pathways of dendritic cells and their clinical significance in immune disorders of sepsis, so as to find new strategies for immune regulation of sepsis.
脓毒症是由宿主对感染的失调反应引起的危及生命的器官功能障碍。脓毒症的进一步发展通常会导致感染性休克甚至死亡。以往许多研究集中在脓毒症中单核细胞/巨噬细胞、中性粒细胞、补体系统或细胞因子炎症的异常反应。近年来许多证据表明，树突状细胞作为机体固有免疫系统中最强大的抗原呈递细胞，在脓毒症免疫紊乱过程中发挥重要作用。在本文中，我综述了树突状细胞的主要分类、免疫功能、监测方法、调节途径及其在脓毒症免疫紊乱中的临床意义，以期找到脓毒症免疫调节的新策略。
