Children's Health Queensland Clinical Unit, School of Clinical Medicine, Mater Research, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia.
Mol Immunol. 2018 Sep;101:615-626. doi: 10.1016/j.molimm.2018.07.007. Epub 2018 Jul 13.
Sepsis is a disease of dysfunctional immune response against the pathogen causing a profound immune-mediated damage to the vital organs and death of the patient in most cases. However, when sepsis is described much attention is given to monocytes/macrophages, complement system, neutrophils, cytokine storm, and T cells. Dendritic cells (DCs) get less attention in this scenario despite comprising the major immune cell population. Therefore the present review is designed to highlight the importance of DCs in the pathogenesis of sepsis, sepsis-associated immunosuppression, and organ damage. The article starts with an introduction of sepsis as a major medical problem needing an urgent therapeutic targeting. Thereafter it provides a brief information regarding classical and plasmacytoid DCs and their role in the maintenance of immune homeostasis. The subsequent sections describe the role of DCs in the immunopathogenesis of sepsis via immunoregulation, impact of sepsis on DCs including their immunometabolic changes, and their therapeutic targeting during sepsis.
脓毒症是一种针对病原体的免疫功能失调性疾病，它会导致重要器官的严重免疫介导损伤，大多数情况下患者会因此死亡。然而，在描述脓毒症时，人们更多地关注单核细胞/巨噬细胞、补体系统、中性粒细胞、细胞因子风暴和 T 细胞。在这种情况下，树突状细胞 (DC) 受到的关注较少，尽管它们构成了主要的免疫细胞群体。因此，本综述旨在强调 DC 在脓毒症发病机制、脓毒症相关免疫抑制和器官损伤中的重要性。文章首先介绍了脓毒症作为一个需要紧急治疗靶向的主要医学问题。此后，它提供了关于经典和浆细胞样 DC 及其在维持免疫稳态中的作用的简要信息。随后的部分描述了 DC 通过免疫调节在脓毒症免疫发病机制中的作用、脓毒症对 DC 的影响，包括它们的免疫代谢变化，以及在脓毒症期间对它们的治疗靶向。
