钯催化环状α,β-不饱和O-甲基肟与芳基碘的β-芳基化反应
Palladium-Catalyzed β-Arylation of Cyclic α,β-Unsaturated O-Methyl Oximes with Aryl Iodides.
作者信息
Akagi Yusuke, Fukuyama Shiori, Komatsu Toshiya
机构信息
Faculty of Pharmaceutical Sciences, Teikyo Heisei University.
出版信息
Chem Pharm Bull (Tokyo). 2020;68(3):288-291. doi: 10.1248/cpb.c19-01012.
PMID:32115536
Abstract
We report a Pd-catalyzed β-arylation of cyclic α,β-unsaturated O-methyl oximes with aryl iodides. This reaction shows complete regioselectivity and excellent functional group tolerance. β-Arylation of 2-cyclohexen-1-one O-methyl oxime (existing as 2 : 1 E/Z mixture) with certain aryl iodides such as 4-iodoanisole affords only β-arylated (E)-O-methyl oximes.
摘要
我们报道了钯催化环状α,β-不饱和O-甲基肟与芳基碘化物的β-芳基化反应。该反应具有完全的区域选择性和出色的官能团耐受性。2-环己烯-1-酮O-甲基肟（以2∶1的E/Z混合物形式存在）与某些芳基碘化物（如4-碘苯甲醚）的β-芳基化反应仅生成β-芳基化的（E）-O-甲基肟。
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