疾病进展过程中的接触模式变化：以尼帕病毒为例。
Changing Contact Patterns Over Disease Progression: Nipah Virus as a Case Study.
机构信息
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mathematical Modelling of Infectious Diseases Unit Institut Pasteur, Paris, France.
出版信息
J Infect Dis. 2020 Jul 6;222(3):438-442. doi: 10.1093/infdis/jiaa091.
Contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. We used surveys among 1642 contacts of 94 Nipah virus case patients in Bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. The number of contacts increased with severity and, for case patients who died, peaked on the day of death. Given transmission has only been observed among fatal cases of Nipah virus infection, our findings suggest that changes in contact patterns during illness contribute to risk of infection.
接触模式在疾病传播中起着关键作用，疾病过程中接触的变化会影响传播，尤其是当宿主传染性发生变化时。我们对孟加拉国 94 例尼帕病毒病例的 1642 名接触者进行了调查，以确定随着疾病严重程度的变化，接触模式（身体接触和体液接触）如何变化。接触者的数量随着严重程度的增加而增加，对于死亡的病例患者，在死亡当天达到峰值。鉴于尼帕病毒感染的致死病例中仅观察到了传播，我们的研究结果表明，疾病过程中接触模式的变化会增加感染的风险。
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