Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P.R. China.
CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P.R. China.
J Am Chem Soc. 2020 Mar 25;142(12):5649-5656. doi: 10.1021/jacs.9b12929. Epub 2020 Mar 12.
Pd nanosheets (Pd NSs) have attracted extensive attention due to their promising application in photothermal therapy. However, their photodynamic properties have rarely been reported. Herein, holey Pd NSs (H-Pd NSs) with intrinsic photodynamic and hypoxia-resistant capacities are fabricated for the first time using an anisotropic oxidative etching strategy, which introduces one-dimensional nanoholes with active (100) facets on the hole walls. Gradual degradation of H-Pd NSs is observed in simulated physiological media due to the oxidative etching. and studies indicate that the single-component H-Pd NSs can act as a photothermal/photodynamic agent for imaging-guided hypoxic tumor therapy, with a high tumor inhibition rate of 99.7%. This work provides ideas for introducing active facets in metallic pore walls, broadening the application of Pd NSs and the design of biodegradable noble metal nanotheranostic agents for cancer therapy.
Pd 纳米片（Pd NSs）由于在光热治疗中的应用前景广阔而受到广泛关注。然而，其光动力性质很少有报道。本文首次采用各向异性氧化刻蚀策略制备具有内在光动力和抗缺氧能力的多孔 Pd 纳米片（H-Pd NSs），在孔壁上引入具有活性（100）面的一维纳米孔。在模拟生理介质中观察到 H-Pd NSs 的逐渐降解，这是由于氧化刻蚀所致。 和 研究表明，单一成分的 H-Pd NSs 可以作为一种光热/光动力试剂，用于成像引导的缺氧肿瘤治疗，肿瘤抑制率高达 99.7%。这项工作为在金属孔壁中引入活性面提供了思路，拓宽了 Pd NSs 的应用范围，并为癌症治疗设计了可生物降解的贵金属纳米治疗剂。
