Department of Abdominal Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China.
Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China.
Int J Biol Sci. 2024 Oct 14;20(14):5673-5694. doi: 10.7150/ijbs.100317. eCollection 2024.
Photodynamic therapy (PDT) represents a targeted approach for cancer treatment that employs light and photosensitizers (PSs) to induce the generation of reactive oxygen species (ROS). However, PDT faces obstacles including insufficient PS localization, limited light penetration, and treatment resistance. A potential solution lies in nanogenerators (NGs), which function as self-powered systems capable of generating electrical energy. Recent progress in piezoelectric and triboelectric NGs showcases promising applications in cancer research and drug delivery. Integration of NGs with PDT holds the promise of enhancing treatment efficacy by ensuring sustained PS illumination, enabling direct electrical control of cancer cells, and facilitating improved drug administration. This comprehensive review aims to augment our comprehension of PDT principles, explore associated challenges, and underscore the transformative capacity of NGs in conjunction with PDT. By harnessing NG technology alongside PDT, significant advancement in cancer treatment can be realized. Herein, we present the principal findings and conclusions of this study, offering valuable insights into the integration of NGs to overcome barriers in PDT.
光动力疗法（PDT）代表了一种针对癌症治疗的靶向方法，它利用光和光敏剂（PSs）来诱导活性氧物质（ROS）的产生。然而，PDT 面临着一些障碍，包括 PS 定位不足、有限的光穿透性和治疗抵抗性。一种潜在的解决方案在于纳米发电机（NGs），它作为自供电系统，可以产生电能。压电和摩擦电 NGs 的最新进展展示了在癌症研究和药物输送方面的有前途的应用。将 NGs 与 PDT 结合有望通过确保持续的 PS 照射、实现对癌细胞的直接电控制以及促进药物管理的改善来提高治疗效果。本综述旨在增强我们对 PDT 原理的理解，探讨相关挑战，并强调 NGs 与 PDT 结合的变革能力。通过将 NG 技术与 PDT 结合使用，可以实现癌症治疗的重大进展。在这里，我们呈现了这项研究的主要发现和结论，为克服 PDT 中的障碍，整合 NGs 提供了有价值的见解。
