Abacioglu O Ozcan
Bratisl Lek Listy. 2020;121(2):151-153. doi: 10.4149/BLL_2020_021.
Mitral valve prolapse (MVP) is a common disorder, afflicting 2 % to 3 % of the general population. Despite the general belief of a benign disorder, there is an increasing awareness of an association between mitral valve prolapse and sudden cardiac death from arrhythmia and also atherosclerosis. Monocyte to high density lipoprotein ratio (MHR) is a new tool for predicting inflammation, which plays a major role in atherosclerosis.
To evaluate the relationship between MHR and the presence of MVP.
The study population consisted of 82 patients with MVP and the control group of 78 normal individuals. Transthoracic echocardiograpy was performed for all of the study population and peripheral venous blood samples were drawn for measuring MHR and other haemotological parameters.
The patients with MVP were more likely to have higher MHR values (15.82±6.01 in MVP patients and 13.30 ± 6.43 in controls; p=0.011). Monocyte counts and MHR of the MVP group were significantly higher than the control group and MHR values were directly proportional with the regurgitation area.
The MHR is strongly associated with MVP and regurgitation area and might be a prognostic factor for patients with MVP (Tab. 3, Fig. 1, Ref. 15).
二尖瓣脱垂（MVP）是一种常见疾病，在普通人群中的发病率为2%至3%。尽管人们普遍认为这是一种良性疾病，但二尖瓣脱垂与心律失常导致的心脏性猝死以及动脉粥样硬化之间的关联正日益受到关注。单核细胞与高密度脂蛋白比值（MHR）是预测炎症的一种新工具，炎症在动脉粥样硬化中起主要作用。
评估MHR与MVP存在之间的关系。
研究人群包括82例MVP患者和78名正常个体组成的对照组。对所有研究人群进行经胸超声心动图检查，并采集外周静脉血样本以测量MHR和其他血液学参数。
MVP患者更有可能具有较高的MHR值（MVP患者为15.82±6.01，对照组为13.30±6.43；p = 0.011）。MVP组的单核细胞计数和MHR显著高于对照组，且MHR值与反流面积成正比。
MHR与MVP和反流面积密切相关，可能是MVP患者的一个预后因素（表3，图1，参考文献15）。
