• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Elevated Monocyte to High-density Lipoprotein Ratios as an Inflammation Markers for Schizophrenia Patients.单核细胞与高密度脂蛋白比值升高作为精神分裂症患者的炎症标志物
Clin Psychopharmacol Neurosci. 2021 Feb 28;19(1):112-116. doi: 10.9758/cpn.2021.19.1.112.
2
The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia.单核细胞/高密度脂蛋白比值（MHR）及阳性症状评分对精神分裂症患者攻击行为的预测价值。
Medicina (Kaunas). 2023 Mar 3;59(3):503. doi: 10.3390/medicina59030503.
3
Clinical and Diagnostic Value of High-Density Lipoprotein-Based Inflammatory Indices and Lipid Ratios in Young Adults with Schizophrenia.基于高密度脂蛋白的炎症指标和脂质比率在年轻精神分裂症患者中的临床及诊断价值
J Inflamm Res. 2024 Sep 14;17:6363-6374. doi: 10.2147/JIR.S473528. eCollection 2024.
4
Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder.对全身免疫炎症指数、中性粒细胞/高密度脂蛋白比值、淋巴细胞/高密度脂蛋白比值和单核细胞/高密度脂蛋白比值作为精神分裂症和双相情感障碍患者炎症指标的研究。
Front Psychiatry. 2022 Jul 26;13:941728. doi: 10.3389/fpsyt.2022.941728. eCollection 2022.
5
Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia.单核细胞/高密度脂蛋白胆固醇比值作为精神分裂症患者一种新的炎症标志物
J Pers Med. 2023 Jan 31;13(2):276. doi: 10.3390/jpm13020276.
6
Neutrophil/high-density lipoprotein cholesterol (HDL), monocyte/HDL and platelet/HDL ratios are increased in acute mania as markers of inflammation, even after controlling for confounding factors.即使在控制混杂因素后，中性粒细胞/高密度脂蛋白胆固醇（HDL）、单核细胞/HDL和血小板/HDL比值在急性躁狂症中仍会升高，作为炎症标志物。
Curr Med Res Opin. 2023 Oct;39(10):1383-1390. doi: 10.1080/03007995.2023.2260302. Epub 2023 Oct 10.
7
Elevated Monocyte-to-High-Density Lipoprotein Ratio as an Indicator of Systemic Inflammation in Patients with Branch Retinal Vein Occlusion.单核细胞与高密度脂蛋白比值升高作为视网膜分支静脉阻塞患者全身炎症的指标
Beyoglu Eye J. 2021 Sep 24;6(3):212-216. doi: 10.14744/bej.2021.94547. eCollection 2021.
8
A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking.一种新的炎症标志物：单核细胞与高密度脂蛋白胆固醇比值升高与吸烟相关
J Clin Med. 2018 Apr 10;7(4):76. doi: 10.3390/jcm7040076.
9
Effects of Major Depressive Disorder on Monocytes, High-Density Lipoprotein (HDL) and Monocyte to HDL Ratio: A Case-Control Study.重度抑郁症对单核细胞、高密度脂蛋白（HDL）及单核细胞与HDL比值的影响：一项病例对照研究。
Psychiatr Danub. 2022 Winter;34(4):687-694. doi: 10.24869/psyd.2022.687.
10
Evaluation of Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Presence and Severity of Metabolic Syndrome.代谢综合征存在及严重程度下单核细胞与高密度脂蛋白胆固醇比值的评估
Clin Appl Thromb Hemost. 2018 Jul;24(5):828-833. doi: 10.1177/1076029617741362. Epub 2017 Dec 6.

引用本文的文献

1
Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?多巴胺假说的六十年：芳烃受体是新的D2受体吗？
Reports (MDPI). 2023 Aug 1;6(3):36. doi: 10.3390/reports6030036.
2
Differences in Blood Leukocyte Subpopulations in Schizophrenia: A Systematic Review and Meta-Analysis.精神分裂症患者血液白细胞亚群的差异：一项系统评价和荟萃分析。
JAMA Psychiatry. 2025 May 1;82(5):492-504. doi: 10.1001/jamapsychiatry.2024.4941.
3
Combined Predictors for the Diagnostic Transition from Acute and Transient Psychotic Disorder to Schizophrenia: A Retrospective Study.从急性短暂性精神病性障碍向精神分裂症诊断转变的联合预测因素：一项回顾性研究
Neuropsychiatr Dis Treat. 2024 Oct 27;20:2029-2037. doi: 10.2147/NDT.S470127. eCollection 2024.
4
Clinical and Diagnostic Value of High-Density Lipoprotein-Based Inflammatory Indices and Lipid Ratios in Young Adults with Schizophrenia.基于高密度脂蛋白的炎症指标和脂质比率在年轻精神分裂症患者中的临床及诊断价值
J Inflamm Res. 2024 Sep 14;17:6363-6374. doi: 10.2147/JIR.S473528. eCollection 2024.
5
Nomogram incorporating preoperative pan-immune-inflammation value and monocyte to high-density lipoprotein ratio for survival prediction in patients with colorectal cancer: a retrospective study.列线图纳入术前全免疫炎症值和单核细胞与高密度脂蛋白比值预测结直肠癌患者生存：一项回顾性研究。
BMC Cancer. 2024 Jun 17;24(1):740. doi: 10.1186/s12885-024-12509-x.
6
The Potential Use of Monocyte-to-High-Density Lipoprotein Ratio as a Chronic Inflammatory Marker in Major Depressive Disorder.单核细胞与高密度脂蛋白比值作为重度抑郁症慢性炎症标志物的潜在用途
Psychiatry Clin Psychopharmacol. 2023 Sep 1;33(3):187-192. doi: 10.5152/pcp.2023.22518. eCollection 2023 Sep.
7
A Comparison of the Relationship Between C-Reactive Protein Levels and Cognitive Functions in Patients with Schizophrenia, First-Episode Psychosis, and Healthy Controls.精神分裂症患者、首发精神病患者及健康对照者中C反应蛋白水平与认知功能关系的比较
Psychiatry Clin Psychopharmacol. 2022 Dec 1;32(4):274-284. doi: 10.5152/pcp.2022.22447. eCollection 2022 Dec.
8
Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior.双相障碍患者犯罪与炎症标志物的关系及其与犯罪行为的关系。
Medicina (Kaunas). 2023 Sep 27;59(10):1725. doi: 10.3390/medicina59101725.
9
The usefulness of a complete blood count in the prediction of the first episode of schizophrenia diagnosis and its relationship with oxidative stress.全血细胞计数在预测精神分裂症首次发作中的作用及其与氧化应激的关系。
PLoS One. 2023 Oct 12;18(10):e0292756. doi: 10.1371/journal.pone.0292756. eCollection 2023.
10
Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings.精神分裂症中免疫功能障碍的小胶质细胞和其他细胞介质：临床研究的综合叙述。
Cells. 2023 Aug 19;12(16):2099. doi: 10.3390/cells12162099.

本文引用的文献

1
Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?单核细胞与高密度脂蛋白比值：二尖瓣脱垂的一个预后因素？
Bratisl Lek Listy. 2020;121(2):151-153. doi: 10.4149/BLL_2020_021.
2
Monocyte/HDL ratio predicts hypertensive complications.单核细胞/高密度脂蛋白比值可预测高血压并发症。
Bratisl Lek Listy. 2020;121(2):133-136. doi: 10.4149/BLL_2020_018.
3
Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge.评估单核细胞/高密度脂蛋白比值与心肌桥的关系。
Arq Bras Cardiol. 2019 Jan;112(1):12-17. doi: 10.5935/abc.20180253. Epub 2018 Dec 17.
4
Antipsychotics, Metabolic Adverse Effects, and Cognitive Function in Schizophrenia.抗精神病药物、代谢不良反应与精神分裂症的认知功能
Front Psychiatry. 2018 Dec 5;9:622. doi: 10.3389/fpsyt.2018.00622. eCollection 2018.
5
A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking.一种新的炎症标志物：单核细胞与高密度脂蛋白胆固醇比值升高与吸烟相关
J Clin Med. 2018 Apr 10;7(4):76. doi: 10.3390/jcm7040076.
6
Increased monocyte-to-HDL cholesterol ratio is related to cardiac syndrome X.单核细胞与高密度脂蛋白胆固醇比值升高与心脏X综合征相关。
Acta Cardiol. 2017 Oct;72(5):516-521. doi: 10.1080/00015385.2017.1299521. Epub 2017 Aug 30.
7
Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome.代谢综合征患者单核细胞与高密度脂蛋白胆固醇比值及淋巴细胞与单核细胞比值的评估。
Biomark Med. 2017 Jul;11(7):535-540. doi: 10.2217/bmm-2016-0380. Epub 2017 Jul 7.
8
Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.合并性及特定严重精神疾病患者心血管疾病的患病率、发病率和死亡率：对3211768例患者和113383368例对照的大规模荟萃分析。
World Psychiatry. 2017 Jun;16(2):163-180. doi: 10.1002/wps.20420.
9
Metabolic adverse effects of olanzapine on cognitive dysfunction: A possible relationship between BDNF and TNF-alpha.奥氮平对认知功能障碍的代谢性不良反应：脑源性神经营养因子与肿瘤坏死因子-α之间的可能关系。
Psychoneuroendocrinology. 2017 Jul;81:138-143. doi: 10.1016/j.psyneuen.2017.04.014. Epub 2017 Apr 27.
10
Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders.精神分裂症谱系障碍患者血清胆红素水平与代谢综合征之间的关系
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):153-162. doi: 10.9758/cpn.2017.15.2.153.

单核细胞与高密度脂蛋白比值升高作为精神分裂症患者的炎症标志物

Elevated Monocyte to High-density Lipoprotein Ratios as an Inflammation Markers for Schizophrenia Patients.

作者信息

Sahpolat Musa, Ayar Duygu, Ari Mustafa, Karaman Mehmet Akif

机构信息

Department of Psychiatry, Kilis State Hospital, Turkey.

Yusuf Serefoglu Faculty of Health Sciences, Kilis 7 Aralık University, Kilis, Turkey.

出版信息

Clin Psychopharmacol Neurosci. 2021 Feb 28;19(1):112-116. doi: 10.9758/cpn.2021.19.1.112.

DOI:10.9758/cpn.2021.19.1.112
PMID:33508794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7851456/
Abstract

OBJECTIVE

Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia.

METHODS

The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants.

RESULTS

The patients with schizophrenia had higher MHR values (15.04 ± 3.31 in schizophrenia patients and 12.62 ± 2.99 in controls; = 0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, body mass index, severity of disease and MHR.

CONCLUSION

To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.

摘要

目的

单核细胞与高密度脂蛋白比值（MHR）是一种提示炎症的新指标，在精神分裂症中起主要作用。因此，在本研究中，我们的目标是调查MHR与精神分裂症之间可能存在的关联。

方法

本研究的参与者包括75例精神分裂症患者和74名健康个体（对照组）。采用阳性和阴性症状量表从患者组收集数据。对所有研究参与者的全血细胞计数参数和血脂谱进行分析。

结果

精神分裂症患者的MHR值更高（精神分裂症患者为15.04±3.31，对照组为12.62±2.99；P = 0.001）。精神分裂症患者的单核细胞计数和MHR显著高于对照组。年龄、体重指数、疾病严重程度与MHR之间存在显著正相关。

结论

据我们所知，本研究首次证明了精神分裂症患者中存在如MHR水平等炎症标志物。精神分裂症患者的单核细胞计数和MHR值均高于对照组。MHR可能是评估精神分裂症患者炎症的一种可用且有用的炎症标志物。