Stone Trevor W
NDORMS, University of Oxford, Oxford, United Kingdom.
Front Oncol. 2020 Feb 4;10:94. doi: 10.3389/fonc.2020.00094. eCollection 2020.
The Epithelial-Mesenchymal Transition (EMT) is an important concept in understanding the processes of oncogenesis, especially with respect to the relationship between cell proliferation and metastatic properties such as spontaneous cell motility, chemotaxic migration and tissue invasion. EMT is now recognized as a more complex phenomenon than an all-or-nothing event, in which different components of the EMT may have distinct roles in the physio-pathological regulation of cell function and which may in turn depend on differential interactions with cell constituents and metabolic products. This mini-review summarizes recent work on the induction of cancer properties in parallel with the presence of EMT activities in the presence of serine proteases, with the focus on those tumor suppressors known as "dependence" receptors such as neogenin and Deleted in Colorectal Cancer (DCC). It is concluded that various forms of partial EMT should be given more detailed investigation and consideration as the results could have valuable implications for the development of disease-specific and patient-specific therapies.
上皮-间质转化（EMT）是理解肿瘤发生过程中的一个重要概念，特别是在细胞增殖与转移特性（如自发细胞运动性、趋化性迁移和组织侵袭）之间的关系方面。EMT现在被认为是一个比全或无事件更为复杂的现象，其中EMT的不同组成部分可能在细胞功能的生理病理调节中具有不同作用，而这反过来可能取决于与细胞成分和代谢产物的差异相互作用。本综述总结了最近关于在丝氨酸蛋白酶存在的情况下，与EMT活性同时诱导癌症特性的研究工作，重点关注那些被称为“依赖”受体的肿瘤抑制因子，如新生成素和结直肠癌缺失基因（DCC）。得出的结论是，应更详细地研究和考虑各种形式的部分EMT，因为其结果可能对疾病特异性和患者特异性治疗的发展具有重要意义。
