Ashrafizadeh Milad, Zarrabi Ali, Saberifar Sedigheh, Hashemi Farid, Hushmandi Kiavash, Hashemi Fardin, Moghadam Ebrahim Rahmani, Mohammadinejad Reza, Najafi Masoud, Garg Manoj
Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz 5166616471, Iran.
Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956 Istanbul, Turkey.
Biomedicines. 2020 May 5;8(5):110. doi: 10.3390/biomedicines8050110.
Cancer therapy is a growing field, and annually, a high number of research is performed to develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer cells are able to acquire resistance to conventional drugs. Natural chemicals can be considered as promising candidates in the field of cancer therapy due to their multiple-targeting capability. The nobiletin (NOB) is a ubiquitous flavone isolated from Citrus fruits. The NOB has a variety of pharmacological activities, such as antidiabetes, antioxidant, anti-inflammatory, hepatoprotective, and neuroprotective. Among them, the antitumor activity of NOB has been under attention over recent years. In this review, we comprehensively describe the efficacy of NOB in cancer therapy. NOB induces apoptosis and cell cycle arrest in cancer cells. It can suppress migration and invasion of cancer cells via the inhibition of epithelial-to-mesenchymal transition (EMT) and EMT-related factors such as TGF-β, ZEB, Slug, and Snail. Besides, NOB inhibits oncogene factors such as STAT3, NF-κB, Akt, PI3K, Wnt, and so on. Noteworthy, onco-suppressor factors such as microRNA-7 and -200b undergo upregulation by NOB in cancer therapy. These onco-suppressor and oncogene pathways and mechanisms are discussed in this review.
癌症治疗是一个不断发展的领域，每年都有大量研究致力于开发新型抗肿瘤药物。由于癌细胞能够对传统药物产生耐药性，寻找新的抗肿瘤药物的尝试仍在继续。天然化学物质因其多靶点作用能力，可被视为癌症治疗领域有潜力的候选物。川陈皮素（NOB）是一种从柑橘类水果中分离出的普遍存在的黄酮类化合物。NOB具有多种药理活性，如抗糖尿病、抗氧化、抗炎、保肝和神经保护作用。其中，NOB的抗肿瘤活性近年来受到关注。在本综述中，我们全面描述了NOB在癌症治疗中的疗效。NOB可诱导癌细胞凋亡和细胞周期停滞。它可以通过抑制上皮-间质转化（EMT）以及EMT相关因子如TGF-β、ZEB、Slug和Snail来抑制癌细胞的迁移和侵袭。此外，NOB还能抑制STAT3、NF-κB、Akt、PI3K、Wnt等致癌基因因子。值得注意的是，在癌症治疗中，NOB可上调如microRNA-7和-200b等抑癌因子。本综述将对这些抑癌和致癌基因途径及机制进行讨论。
