Vanherle Lotte, Matuskova Hana, Don-Doncow Nicholas, Uhl Franziska E, Meissner Anja
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.
Front Cell Dev Biol. 2020 Feb 7;8:53. doi: 10.3389/fcell.2020.00053. eCollection 2020.
Mounting evidence indicates that the presence of cardiovascular disease (CVD) and risk factors elevates the incidence of cognitive impairment (CI) and dementia. CVD and associated decline in cardiovascular function can impair cerebral blood flow (CBF) regulation, leading to the disruption of oxygen and nutrient supply in the brain where limited intracellular energy storage capacity critically depends on CBF to sustain proper neuronal functioning. During hypertension and acute as well as chronic CVD, cerebral hypoperfusion and impaired cerebrovascular function are often associated with neurodegeneration and can lead to CI and dementia. Currently, all forms of neurodegeneration associated to CVD lack effective treatments, which highlights the need to better understand specific mechanisms linking cerebrovascular dysfunction and CBF deficits to neurodegeneration. In this review, we discuss vascular targets that have already shown attenuation of neurodegeneration or CI associated to hypertension, heart failure (HF) and stroke by improving cerebrovascular function or CBF deficits.
越来越多的证据表明，心血管疾病（CVD）及其危险因素的存在会增加认知障碍（CI）和痴呆症的发病率。CVD以及心血管功能的相关衰退会损害脑血流量（CBF）调节，导致大脑中氧气和营养物质供应中断，而大脑中有限的细胞内能量储存能力严重依赖CBF来维持神经元的正常功能。在高血压、急性和慢性CVD期间，脑灌注不足和脑血管功能受损通常与神经退行性变有关，并可导致CI和痴呆症。目前，所有与CVD相关的神经退行性变形式都缺乏有效的治疗方法，这凸显了更好地理解将脑血管功能障碍和CBF不足与神经退行性变联系起来的具体机制的必要性。在这篇综述中，我们讨论了一些血管靶点，这些靶点已显示出通过改善脑血管功能或CBF不足来减轻与高血压、心力衰竭（HF）和中风相关的神经退行性变或CI。
