慢性特发性血小板减少性紫癜治疗后的严重并发症。
Serious complications following treatment of chronic idiopathic thrombocytopenic purpura.
作者信息
Wanachiwanawin W, Visudhiphan S, Piankijagum A, Vatanavicharn S
机构信息
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Postgrad Med J. 1988 Jun;64(752):426-30. doi: 10.1136/pgmj.64.752.426.
Six patients had serious complications as consequences of treatment of idiopathic thrombocytopenic purpura. Five had splenectomy-related complications, one of them developed fatal intra-abdominal bleeding. Three patients acquired operation-related serious infection, two of them died. Serious neutropenia after vinblastine-loaded platelets occurred in one patient leading to pseudomonas septicaemia and panophthalmitis with permanent vision loss of left eye. Recurrence thrombocytopenia occurred in every case during serious complications. Early detection by awareness of the possibility of serious complications can reduce morbidity and mortality occurring after therapy of idiopathic thrombocytopenic purpura.
6例特发性血小板减少性紫癜患者在治疗过程中出现严重并发症。5例发生与脾切除术相关的并发症，其中1例发生致命性腹腔内出血。3例出现与手术相关的严重感染，其中2例死亡。1例患者在输注长春碱负载的血小板后出现严重中性粒细胞减少，导致铜绿假单胞菌败血症和全眼球炎，左眼永久性视力丧失。在严重并发症发生时，每例患者均出现血小板减少复发。通过认识到严重并发症的可能性进行早期检测，可降低特发性血小板减少性紫癜治疗后发生的发病率和死亡率。
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