Sukenik S, el-Roeiy A, Shoenfeld Y
Acta Haematol. 1986;76(2-3):86-9. doi: 10.1159/000206027.
The lupus anticoagulant (LA) is an acquired autoantibody of the IgG or IgM type that acts on platelet factor III, inhibiting the generation of the prothrombin activator complex. It is prevalent in 5-10% of SLE cases and, in contradistinction to the name anticoagulant, it may be associated with thrombotic events, recurrent abortion or intrauterine death. Anti-cardiolipin antibody like LA, is an anti-phospholipid antibody and also causes recurrent thrombotic events. Mention has been made of a possible cross-reactivity between anti-phospholipid antibodies and anti-DNA antibodies. The optimal treatment for this problem is at present unknown.
狼疮抗凝物（LA）是一种获得性IgG或IgM型自身抗体，作用于血小板因子III，抑制凝血酶原激活物复合物的生成。它在5%至10%的系统性红斑狼疮（SLE）病例中普遍存在，与抗凝物这个名称相反，它可能与血栓形成事件、反复流产或宫内死亡有关。与LA一样，抗心磷脂抗体也是一种抗磷脂抗体，也会导致反复血栓形成事件。已经提到抗磷脂抗体和抗DNA抗体之间可能存在交叉反应。目前对于这个问题的最佳治疗方法尚不清楚。
