宫内移植后人类嵌合非整倍体囊胚的结局：一项回顾性研究。
The outcome of human mosaic aneuploid blastocysts after intrauterine transfer: A retrospective study.
作者信息
Hong Baoli, Hao Yan
机构信息
Department of Obstetrics and Gynecology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, Anhui.
Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, P.R. China.
出版信息
Medicine (Baltimore). 2020 Feb;99(9):e18768. doi: 10.1097/MD.0000000000018768.
To explore whether mosaic/aneuploid embryos can be transferred when there is no normal embryo available for transplant.The clinical pregnancy outcomes and amniocentesis outcomes of transplanted mosaic embryos during 28 preimplantation genetic testing (PGT) cycles were retrospectively analyzed. Chromosomes of 4 donated mosaic blastocysts were comprehensively screened by next-generation sequencing.About 10 (35.7%) of the 28 transferred mosaic embryos were implanted and had a gestational sac. But 5 women miscarried due to lack of fetal heartbeat between the 7th and 12th week of pregnancy. Five women had full-term pregnancies and gave birth to 5 healthy babies. Three of the 4 donated mosaic blastocysts had normal trophectoderm and inner cell mass, but the other 1 had abnormal embryonic cell mass.When no normal transplantable embryo is available in the PGT cycles, but the underlying risk must be fully informed.
探讨在没有正常胚胎可供移植时，嵌合/非整倍体胚胎是否可以进行移植。回顾性分析了28个植入前基因检测（PGT）周期中移植嵌合胚胎的临床妊娠结局和羊水穿刺结果。通过下一代测序对4个捐赠的嵌合囊胚的染色体进行了全面筛查。28个移植的嵌合胚胎中约有10个（35.7%）着床并出现妊娠囊。但有5名女性在妊娠第7至12周期间因胎儿心跳停止而流产。5名女性足月妊娠并产下5名健康婴儿。4个捐赠的嵌合囊胚中有3个滋养外胚层和内细胞团正常，但另1个胚胎细胞团异常。在PGT周期中没有正常的可移植胚胎时，但必须充分告知潜在风险。
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