Zhang Longguo, Wu Fanqi, Zhu Rui, Wu Di, Ding Yao, Zhang Zhongmei, Gao Ya, Wan Yixin
The Second Clinical Medical School of Lanzhou University.
Department of Respiratory, Lanzhou University Second Hospital.
Medicine (Baltimore). 2020 Feb;99(9):e19314. doi: 10.1097/MD.0000000000019314.
Ruling out distant metastases, non-small cell lung cancer (NSCLC)treatment depends on the results of mediastinal node staging (N staging). Several diagnostic methods play central roles in mediastinal N staging. This study is intended to evaluate the existing diagnostic methods and report quality, and to search for the best method for staging mediastinal lymph nodes.
We searched PubMed, Embase, and the Cochrane Library to identify relevant studies, including randomized controlled trials and retrospective studies. These studies report the application of computed tomography, positron emission tomography-computed tomography, magnetic resonance imaging, endobronchial ultrasound, and mediastinoscopy in the diagnosis of mediastinal lymph node staging of NSCLC. The quality of the literature was assessed using the Quality Assessment of Diagnostic Accuracy Study 2. The true positive, false positive, true negative, and false negative of each study was extracted. The corresponding sensitivity, specificity, and other indicators were calculated and the Summary Receiver Operating curve was established. Then, head-to-head and indirect comparison meta-analyses will be conducted.
The results of this study will be published in a peer-reviewed journal.
This study will provide basis for mediastinal lymph node staging of non-small cell lung cancer.
CRD42019145667.
在排除远处转移的情况下，非小细胞肺癌（NSCLC）的治疗取决于纵隔淋巴结分期（N分期）的结果。几种诊断方法在纵隔N分期中起着核心作用。本研究旨在评估现有的诊断方法及其报告质量，并寻找纵隔淋巴结分期的最佳方法。
我们检索了PubMed、Embase和Cochrane图书馆，以识别相关研究，包括随机对照试验和回顾性研究。这些研究报告了计算机断层扫描、正电子发射断层扫描-计算机断层扫描、磁共振成像、支气管内超声和纵隔镜检查在NSCLC纵隔淋巴结分期诊断中的应用。使用诊断准确性研究质量评估2对文献质量进行评估。提取每项研究的真阳性、假阳性、真阴性和假阴性。计算相应的敏感性、特异性和其他指标，并建立汇总接受者操作曲线。然后，将进行直接比较和间接比较的荟萃分析。
本研究结果将发表在同行评审期刊上。
本研究将为非小细胞肺癌纵隔淋巴结分期提供依据。
PROSPERO注册号：CRD42019145667。
