Jatwani Shraddha, Hearth Holmes Michelene P.
Dignity Health Mercy Medical Group
UNMC
Lupus erythematosus is an inflammatory connective tissue disorder characterized by pathogenic autoantibody production and immune complex formation and deposition resulting from a loss of immune tolerance. Dermatological manifestations of lupus constitute one of the diagnostic criteria for systemic lupus erythematosus (SLE). Cutaneous manifestations in lupus cover a broad spectrum and may or may not occur in the context of SLE. The lesions may be described as lupus erythematosus-specific and lupus erythematosus-nonspecific. Lupus erythematosus-specific manifestations include various subtypes of cutaneous lupus erythematosus (CLE) and are subdivided into 3 different categories described by Gillian et al. These categories are acute, subacute, and chronic CLE. This activity provides updated information on subacute CLE (SCLE), which typically presents as a symmetric, nonscarring, photosensitive erythematous rash over sun-exposed areas such as the face, neck, arms, upper back, and shoulders (see . Subacute Cutaneous Lupus Erythematosus Face and Neck Lesions).
红斑狼疮是一种炎症性结缔组织疾病，其特征是由于免疫耐受丧失而产生致病性自身抗体，并形成和沉积免疫复合物。狼疮的皮肤表现是系统性红斑狼疮（SLE）的诊断标准之一。狼疮的皮肤表现范围广泛，可能发生在SLE背景下，也可能不发生。这些病变可分为特异性红斑狼疮和非特异性红斑狼疮。特异性红斑狼疮表现包括各种皮肤型红斑狼疮（CLE）亚型，由吉利安等人分为3个不同类别。这些类别是急性、亚急性和慢性CLE。本活动提供了关于亚急性CLE（SCLE）的最新信息，其通常表现为对称、无瘢痕、光敏性红斑皮疹，出现在面部、颈部、手臂、上背部和肩部等阳光暴露部位（见图。亚急性皮肤型红斑狼疮面部和颈部病变）。
