Zhang Yu-Chen, Geng Rui-Long, Song Jin, Gong Liu-Zhu
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
Org Lett. 2020 Mar 20;22(6):2261-2265. doi: 10.1021/acs.orglett.0c00461. Epub 2020 Mar 2.
Asymmetric annulation of bench-stable α,β-unsaturated aryl esters with enamines was realized via cooperative catalysis of chiral isothiourea and Brønsted acid. This reaction proceeds via a chiral α,β-unsaturated acyl ammonium intermediate and offers a rapid access to functionalized 3,4-dihydropyridin-2-ones in high yields and excellent enantioselectivities.
通过手性异硫脲和布朗斯特酸的协同催化，实现了稳定的α,β-不饱和芳基酯与烯胺的不对称环化反应。该反应通过手性α,β-不饱和酰基铵中间体进行，能够快速高效地获得官能化的3,4-二氢吡啶-2-酮，产率高且对映选择性优异。
