McMillan D E, Evans R L
Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
Pharmacol Biochem Behav. 1988 Jul;30(3):753-4. doi: 10.1016/0091-3057(88)90094-9.
Apomorphine has been reported to increase shock-suppressed drinking, which suggests that it might have antianxiety activity. Because some drugs that increase shock-suppressed drinking are not active in other punishment procedures, the effects of apomorphine on punished and unpunished responding maintained by a multiple fixed-interval, fixed-interval schedule of food presentation were studied in rats. At doses from 3.125 to 100 micrograms/kg, apomorphine failed to increase punished or unpunished responding. In contrast, pentobarbital produced large increases in punished responding maintained by a fixed-interval schedule of food presentation.
据报道，阿扑吗啡可增加电击抑制饮水，这表明它可能具有抗焦虑活性。由于一些增加电击抑制饮水的药物在其他惩罚程序中无活性，因此在大鼠中研究了阿扑吗啡对由多次固定间隔、固定间隔食物呈现时间表维持的受罚和未受罚反应的影响。在3.125至100微克/千克的剂量下，阿扑吗啡未能增加受罚或未受罚反应。相比之下，戊巴比妥使由固定间隔食物呈现时间表维持的受罚反应大幅增加。
