Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
Brain Res Bull. 2020 May;158:84-89. doi: 10.1016/j.brainresbull.2020.02.017. Epub 2020 Feb 28.
Insomnia, intelligence and neuroticism are three typical traits and dysfunctions mainly regulated by human brain. Our research aimed to explore the potential genetic relationships between brain function related traits and more than 3000 human plasma proteins.
We conducted a large-scale genetic correlation scan of human plasma proteins and three brain function related traits, including insomnia, intelligence and neuroticism. Linkage disequilibrium score regression (LDSC) analysis was performed to estimate the genetic correlations between each of the blood proteins and insomnia, intelligence and neuroticism via utilizing the genome-wide association study summary statistics of plasma proteins and those three traits.
LDSC analysis identified 18 specific plasma proteins shown suggestive genetic correlations with insomnia such as Periostin (coefficient=-0.3910, P value = 0.0070). Twenty-one plasma proteins exhibited genetic correlations with intelligence such as Ecto-ADP-ribosyltransferase 3 (coefficient = 0.3066, P value = 0.0013). Six specific plasma proteins shown suggestive genetic correlations with neuroticism, such as CD70 antigen (coefficient = 0.2979, P value = 0.0134). After further comparing the suggestive proteins between insomnia, intelligence and neuroticism, we detected 3 common plasma proteins shared by insomnia and intelligence such as Periostin (coefficient =-0.3910, P value = 0.0070; coefficient =0.2673, P value = 0.0159) and Neurexin-1 (coefficient =-0.2913, P value = 0.0197; coefficient = 0.2399, P value = 0.0035). We also detected 2 common plasma proteins shared by intelligence and neuroticism, including CD70 antigen (coefficient =-0.2092, P value = 0.0337; coefficient = 0.2979, P value = 0.0134).
Our results provide novel clues for unveiling the functional relevance of plasma proteins and brain function related traits.
失眠、智力和神经质是三个典型的特征和功能障碍，主要由人脑调节。我们的研究旨在探索脑功能相关特征与 3000 多种人类血浆蛋白之间潜在的遗传关系。
我们对人类血浆蛋白和三种脑功能相关特征（失眠、智力和神经质）进行了大规模的遗传相关性扫描。通过利用血浆蛋白和这三种特征的全基因组关联研究汇总统计数据，进行连锁不平衡得分回归（LDSC）分析，估计每个血液蛋白与失眠、智力和神经质之间的遗传相关性。
LDSC 分析确定了 18 种特定的血浆蛋白与失眠具有提示性的遗传相关性，例如 Periostin（系数=-0.3910，P 值=0.0070）。21 种血浆蛋白与智力具有遗传相关性，例如 Ecto-ADP-ribosyltransferase 3（系数=0.3066，P 值=0.0013）。6 种特定的血浆蛋白与神经质具有提示性的遗传相关性，例如 CD70 抗原（系数=0.2979，P 值=0.0134）。在进一步比较失眠、智力和神经质之间的提示性蛋白后，我们检测到 3 种共同的血浆蛋白，它们在失眠和智力中都有发现，例如 Periostin（系数=-0.3910，P 值=0.0070；系数=0.2673，P 值=0.0159）和 Neurexin-1（系数=-0.2913，P 值=0.0197；系数=0.2399，P 值=0.0035）。我们还检测到 2 种在智力和神经质中都有发现的共同血浆蛋白，包括 CD70 抗原（系数=-0.2092，P 值=0.0337；系数=0.2979，P 值=0.0134）。
我们的研究结果为揭示血浆蛋白和脑功能相关特征的功能相关性提供了新的线索。
