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斯里兰卡10至18岁儿童中的维生素D缺乏情况。

Vitamin D deficiency among children aged 10-18 years in Sri Lanka.

作者信息

Jayatissa Renuka, Lekamwasam Sarath, Ranbanda Jayawardana M., Ranasingha Samantha, Perera Amila G., De Silva Krishan H.

机构信息

Medical Research Institute, Colombo 08, Sri Lanka,

出版信息

Ceylon Med J. 2019 Dec 31;64(4):146-154. doi: 10.4038/cmj.v64i4.8991.

Abstract

BACKGROUND

Vitamin D deficiency (VDD) and insufficiency (VDI) are public health problems in many countries, and limited data is available on the prevalence of VDD/VDI in Sri Lanka.

OBJECTIVES

To determine the prevalence and associated factors of VDD in children aged 10- 18 years.

METHODS

This was a cross-sectional study among school children aged 10-18 years at national level. A representative sample of 2525 children were recruited from July to November 2017. Serum 25(OH)D concentration and the patterns of vitamin D rich foods consumption were assessed. VDD and VDI cut offs were set at serum 25(OH)D concentrations of <12 ng/mL and 12-20 ng/mL, respectively as defined by global consensus in 2016.

RESULTS

The mean serum 25(OH)D level was 19.3±7.4 ng/mL. The prevalence of VDD and VDI were 13.2% (95%CI: 11.9%-14.5%) and 45.6% (95%CI: 43.7%-47.5%), respectively. The prevalence of VDD was highest in the central province (32.2%) and highest prevalence of VDI was in the Inabaragamuwa province (58.9%). VDD and VDI were lowest in North Central province (0.7% and 34.7%, respectively). Significantly higher serum 25(OH)D levels were observed with male gender (p=0.000), BMI for age <-2SD (p=0.000), daily milk consumption (p=0.000) and residing in dry zone (p=0.0

CONCLUSIONS

Though Sri Lanka is a tropical country, VDD is prevalent among school children aged 10-18 years. It is important to develop a VDD preventive strategy, especially for high risk groups.

摘要

背景背景背景

维生素D缺乏(VDD)和不足(VDI)在许多国家都是公共卫生问题,而关于斯里兰卡VDD/VDI患病率的数据有限。

目的

确定10至18岁儿童中VDD的患病率及相关因素。

方法

这是一项在全国范围内针对10至18岁在校儿童开展的横断面研究。2017年7月至11月招募了2525名具有代表性的儿童样本。评估血清25(OH)D浓度以及富含维生素D食物的消费模式。根据2016年全球共识,VDD和VDI的临界值分别设定为血清25(OH)D浓度<12 ng/mL和12 - 20 ng/mL。

结果

血清25(OH)D平均水平为19.3±7.4 ng/mL。VDD和VDI的患病率分别为13.2%(95%CI:11.9% - 14.5%)和45.6%(95%CI:43.7% - 47.5%)。VDD患病率在中央省最高(32.2%),VDI患病率在伊纳巴拉加穆瓦省最高(58.9%)。北中央省的VDD和VDI最低(分别为0.7%和34.7%)。男性、年龄别BMI<-2SD、每日饮用牛奶以及居住在干旱地区的儿童血清25(OH)D水平显著更高(p = 0.000)。

结论

尽管斯里兰卡是一个热带国家,但VDD在10至18岁的在校儿童中普遍存在。制定VDD预防策略非常重要,尤其是针对高危人群。

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