Jayatissa Renuka, Lekamwasam Sarath, Ranbanda Jayawardana M., Ranasingha Samantha, Perera Amila G., De Silva Krishan H.
Medical Research Institute, Colombo 08, Sri Lanka,
Ceylon Med J. 2019 Dec 31;64(4):146-154. doi: 10.4038/cmj.v64i4.8991.
Vitamin D deficiency (VDD) and insufficiency (VDI) are public health problems in many countries, and limited data is available on the prevalence of VDD/VDI in Sri Lanka.
To determine the prevalence and associated factors of VDD in children aged 10- 18 years.
This was a cross-sectional study among school children aged 10-18 years at national level. A representative sample of 2525 children were recruited from July to November 2017. Serum 25(OH)D concentration and the patterns of vitamin D rich foods consumption were assessed. VDD and VDI cut offs were set at serum 25(OH)D concentrations of <12 ng/mL and 12-20 ng/mL, respectively as defined by global consensus in 2016.
The mean serum 25(OH)D level was 19.3±7.4 ng/mL. The prevalence of VDD and VDI were 13.2% (95%CI: 11.9%-14.5%) and 45.6% (95%CI: 43.7%-47.5%), respectively. The prevalence of VDD was highest in the central province (32.2%) and highest prevalence of VDI was in the Inabaragamuwa province (58.9%). VDD and VDI were lowest in North Central province (0.7% and 34.7%, respectively). Significantly higher serum 25(OH)D levels were observed with male gender (p=0.000), BMI for age <-2SD (p=0.000), daily milk consumption (p=0.000) and residing in dry zone (p=0.0
Though Sri Lanka is a tropical country, VDD is prevalent among school children aged 10-18 years. It is important to develop a VDD preventive strategy, especially for high risk groups.
维生素D缺乏(VDD)和不足(VDI)在许多国家都是公共卫生问题,而关于斯里兰卡VDD/VDI患病率的数据有限。
确定10至18岁儿童中VDD的患病率及相关因素。
这是一项在全国范围内针对10至18岁在校儿童开展的横断面研究。2017年7月至11月招募了2525名具有代表性的儿童样本。评估血清25(OH)D浓度以及富含维生素D食物的消费模式。根据2016年全球共识,VDD和VDI的临界值分别设定为血清25(OH)D浓度<12 ng/mL和12 - 20 ng/mL。
血清25(OH)D平均水平为19.3±7.4 ng/mL。VDD和VDI的患病率分别为13.2%(95%CI:11.9% - 14.5%)和45.6%(95%CI:43.7% - 47.5%)。VDD患病率在中央省最高(32.2%),VDI患病率在伊纳巴拉加穆瓦省最高(58.9%)。北中央省的VDD和VDI最低(分别为0.7%和34.7%)。男性、年龄别BMI<-2SD、每日饮用牛奶以及居住在干旱地区的儿童血清25(OH)D水平显著更高(p = 0.000)。
尽管斯里兰卡是一个热带国家,但VDD在10至18岁的在校儿童中普遍存在。制定VDD预防策略非常重要,尤其是针对高危人群。