Mihu Alin Gabriel, Nicolescu Cristian Mircea, Marc Constantin Catalin, Boru Casiana, Susan Monica, Ciceu Alina, Sprintar Sergiu Adrian, Olariu Alexander Tudor, Oatis Daniela Adriana, Nicolescu Laura Corina, Olariu Tudor Rares
Center for Diagnosis and Study of Parasitic Diseases, Department of Infectious Disease, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Bioclinica Medical Analysis Laboratory, Dreptatii Street, No. 23, 310300 Arad, Romania.
Medicina (Kaunas). 2025 Feb 24;61(3):394. doi: 10.3390/medicina61030394.
Adequate levels of vitamin D are vital for both growth and immunomodulation in children. To evaluate the levels of vitamin D in children from Western Romania and to identify significant age, seasonal, and geographical disparities. This study evaluates the level of 25-hydroxyvitamin D levels assessed on Cobas 6000's module e601 in 1698 children aged 1-18 years between 1 January 2018 and 31 December 2021 from Western Romania. : Children aged 1-6 years predominantly present sufficient levels (>30 ng/mL), while older age groups showed a marked decline. Adolescents aged 13-18 years were most affected, with over half displaying insufficient levels (20-30 ng/mL). Rural children were more likely to achieve sufficiency compared to urban peers. Males demonstrated significantly higher vitamin D levels when compared to females. Seasonal variations showed the highest vitamin D levels during late summer and early autumn (September: aOR = 5.47; 95% CI: 3.17-9.42, < 0.001). Multivariate analysis revealed a significant improvement in vitamin D levels during 2019-2020. : Our findings suggest the need for targeted screening programs and health policies to address vitamin D deficiency, particularly among older children, urban residents and during winter months.
充足的维生素D水平对儿童的生长和免疫调节都至关重要。为了评估罗马尼亚西部儿童的维生素D水平，并确定显著的年龄、季节和地理差异。本研究评估了2018年1月1日至2021年12月31日期间，罗马尼亚西部1698名1至18岁儿童在Cobas 6000的e601模块上检测的25-羟基维生素D水平。1至6岁的儿童主要呈现充足水平（>30 ng/mL），而年龄较大的组则显著下降。13至18岁的青少年受影响最大，超过一半的人显示水平不足（20-30 ng/mL）。与城市同龄人相比，农村儿童更有可能达到充足水平。与女性相比，男性的维生素D水平显著更高。季节变化显示，夏末和初秋时维生素D水平最高（9月：调整优势比=5.47；95%置信区间：3.17-9.42，P<0.001）。多变量分析显示，2019-2020年期间维生素D水平有显著改善。我们的研究结果表明，需要有针对性的筛查项目和卫生政策来解决维生素D缺乏问题，特别是在大龄儿童、城市居民以及冬季。
