Department of Ophthalmology, Hospital of Ludwigshafen am Rhein, Ludwigshafen am Rhein, Germany.
Department of Ophthalmology, University of Luebeck, Luebeck, Germany.
Eur J Ophthalmol. 2021 Mar;31(2):556-565. doi: 10.1177/1120672120904670. Epub 2020 Mar 2.
To investigate the significance of the presence and form of pigment epithelial detachment in the course of central serous chorioretinopathy as well as corticosteroid use as a risk in our patient cohort.
Retrospective, single center study of central serous chorioretinopathy patients between January 2013 and January 2019 recording corticosteroid use prior to onset and presence and type of pigment epithelial detachment (flat-irregular, dome-shaped, none) in relationship to disease course.
We analyzed 53 eyes of 53 consecutive central serous chorioretinopathy patients treated in our department. Mean patient age was 53 ± 13 years. A flat-irregular pigment epithelial detachment was associated with either chronic or recurrent central serous chorioretinopathy, whereas the absence of a pigment epithelial detachment correlated positively with acute central serous chorioretinopathy (chi-square test, p < 0.05). Of the 53 patients, 10 reported corticosteroid use, 40 denied steroid use, and 3 patients failed to make a clear statement. Corticosteroid use was not correlated with the onset of central serous chorioretinopathy (Student's t-test, p = 0.0001, chi-square test, p < 0.005).
A small, flat-irregular pigment epithelial detachment could be a marker for chronic or recurrent central serous chorioretinopathy, whereas the absence of pigment epithelial detachment could favor acute central serous chorioretinopathy. Advanced imaging studies may provide more information on the exact characteristics and nature of pigment epithelial detachments. Corticosteroid use as possible disease trigger was not confirmed in this study.
研究色素上皮脱离的存在和形式在中心性浆液性脉络膜视网膜病变病程中的意义，以及皮质类固醇的使用作为我们患者队列中的一个风险因素。
回顾性单中心研究 2013 年 1 月至 2019 年 1 月期间的中心性浆液性脉络膜视网膜病变患者，记录发病前皮质类固醇的使用情况，以及色素上皮脱离（扁平不规则、穹顶状、无）的存在和类型与疾病过程的关系。
我们分析了 53 例在我科治疗的连续中心性浆液性脉络膜视网膜病变患者的 53 只眼。患者平均年龄为 53±13 岁。扁平不规则的色素上皮脱离与慢性或复发性中心性浆液性脉络膜视网膜病变有关，而无色素上皮脱离与急性中心性浆液性脉络膜视网膜病变呈正相关（卡方检验，p<0.05）。53 例患者中，10 例报告皮质类固醇使用，40 例否认类固醇使用，3 例未明确陈述。皮质类固醇的使用与中心性浆液性脉络膜视网膜病变的发病无关（Student's t 检验，p=0.0001，卡方检验，p<0.005）。
小的、扁平不规则的色素上皮脱离可能是慢性或复发性中心性浆液性脉络膜视网膜病变的标志物，而无色素上皮脱离可能有利于急性中心性浆液性脉络膜视网膜病变。先进的成像研究可能提供更多关于色素上皮脱离的确切特征和性质的信息。在这项研究中，皮质类固醇的使用作为可能的疾病触发因素没有得到证实。
