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补充减压与仪器化融合治疗症状性腰椎椎管狭窄症——对现有随机对照试验的批判性评价。

Supplementing decompression with instrumented fusion for symptomatic lumbar spinal stenosis-a critical appraisal of available randomized controlled trials.

机构信息

University of Minnesota, Minneapolis, MN, USA.

出版信息

Neurosurg Rev. 2021 Apr;44(2):643-648. doi: 10.1007/s10143-020-01270-x. Epub 2020 Mar 2.

Abstract

Lumbar spinal stenosis (LSS) is one of the most common indications for surgery in the USA. The addition of instrumented fusion to decompression for the treatment of LSS has become common, but recent randomized controlled trials (RCTs) have produced percieved conflicting results with unclear clinical implications. This review seeks clarity through an analysis of available RCTs. We performed a search of the PubMed database for RCTs that directly addressed decompression vs. decompression and fusion for the surgical treatment of LSS. RCTs were screened and reviewed to compare content such as patient selection, pathology, radiographic criteria, and operative technique. Five RCTs resulted from our search and were included in our analysis. Two studies yielded class I data while three yielded class III data due to study design related issues. Heterogeneity between these studies is emphasized with regard to patient selection, LSS definition, spondylolisthesis, instability, and surgical technique. Efforts to decipher which patients will truly benefit from instrumented fusion for the surgical treatment of LSS are still ongoing. Surgeon judgment will remain a crucial component for surgical decision making until future trials provide clarity. Instrumented fusion should be tailored to the individual patient rather than incorporated as a routine practice.

摘要

腰椎管狭窄症(LSS)是美国最常见的手术指征之一。在减压治疗 LSS 的基础上增加器械融合已变得很常见,但最近的随机对照试验(RCT)得出的结果似乎相互矛盾,其临床意义尚不清楚。本综述通过对现有 RCT 的分析寻求明确性。我们在 PubMed 数据库中进行了一项 RCT 的检索,这些 RCT 直接针对减压与减压融合治疗 LSS 的手术治疗进行了比较。对 RCT 进行了筛选和审查,以比较患者选择、病理学、影像学标准和手术技术等内容。我们的搜索结果有 5 项 RCT,并纳入了我们的分析。其中两项研究产生了 I 级数据,而三项研究由于研究设计相关问题产生了 III 级数据。这些研究之间强调了患者选择、LSS 定义、脊椎滑脱、不稳定性和手术技术方面的异质性。目前仍在努力确定哪些患者真正受益于器械融合治疗 LSS。在未来的试验提供明确性之前,外科医生的判断仍将是手术决策的关键组成部分。器械融合应根据个体患者的情况进行定制,而不是作为常规做法。

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