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[瓣膜狭窄的治疗:外科手术治疗与经皮球囊扩张术]

[Therapy of valvular stenosis: surgical treatment vs percutaneous balloon dilatation].

作者信息

Althaus U

机构信息

Universitätsklinik für Thorax-, Herz- und Gefässchirurgie, Inselspital, Bern.

出版信息

Schweiz Med Wochenschr. 1988 Nov 19;118(46):1681-7.

PMID:3212418
Abstract

Balloon valvuloplasty has been recommended as an alternative to surgery, and therefore this new procedure needs to be compared with cardiac valve replacement. In our experience with 284 consecutive patients, hospital mortality was 1.8% (including multiple valve replacement); 5 years postoperatively survival was 92%, and 94% of the patients had an embolism-free course. To investigate the efficiency of balloon valvuloplasty, this procedure was carried out under direct vision in the operating room prior to excision and replacement of the calcified aortic valve. In two-thirds of patients balloon dilatation did not have a detectable impact on valvular anatomy. In clinical reports the calculated mean aortic valve area did not exceed 1 cm2 (orifice area of the St. Jude valve No. 25 = 3.07 cm2). A good functional result can only be expected from mitral balloon valvuloplasty in the absence of sclerotic alterations of the subvalvular structures. As regards the risk of balloon valvuloplasty for the patient, hospital mortality associated with this procedure is not below that of surgical valve replacement (6.2% in the French Registry for balloon dilatation, 1.8% in our own experience for surgical patients aged over 70 years). An alarming observation is that the beneficial effect of aortic balloon valvuloplasty on the pressure gradient ceases within a relatively short period. For patients with mitral balloon dilatation the risk of arterial thromboembolism and the development of valvular regurgitation must be taken into consideration. The area of clinical application for Balloon valvuloplasty can at present be outlined as follows. The procedure is regarded as the treatment of choice only for pulmonary stenosis. For congenital and rheumatic aortic valve stenosis balloon dilatation may be a useful method for younger individuals if the cusps are not immobilized by calcified masses.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

球囊瓣膜成形术已被推荐作为手术的替代方法,因此需要将这种新手术与心脏瓣膜置换术进行比较。根据我们对284例连续患者的经验,医院死亡率为1.8%(包括多瓣膜置换);术后5年生存率为92%,94%的患者无栓塞发生。为了研究球囊瓣膜成形术的效果,在切除和置换钙化主动脉瓣之前,在手术室直视下进行了该手术。在三分之二的患者中,球囊扩张对瓣膜解剖结构没有可检测到的影响。在临床报告中,计算出的平均主动脉瓣面积不超过1平方厘米(圣犹达25号瓣膜的开口面积=3.07平方厘米)。只有在二尖瓣球囊瓣膜成形术不存在瓣下结构硬化改变的情况下,才能预期获得良好的功能结果。至于球囊瓣膜成形术对患者的风险,与该手术相关的医院死亡率并不低于手术瓣膜置换术(法国球囊扩张登记处为6.2%,我们自己的经验中70岁以上手术患者为1.8%)。一个令人担忧的观察结果是,主动脉球囊瓣膜成形术对压力梯度的有益作用在相对较短的时间内就会消失。对于二尖瓣球囊扩张的患者,必须考虑动脉血栓栓塞的风险和瓣膜反流的发生。目前,球囊瓣膜成形术的临床应用范围可概述如下。该手术仅被视为肺动脉狭窄的首选治疗方法。对于先天性和风湿性主动脉瓣狭窄,如果瓣叶未被钙化块固定,球囊扩张对于较年轻的个体可能是一种有用的方法。(摘要截短至250字)

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