Department of Vascular Interventional, Binzhou Medical University Hospital, Binzhou, China.
Department of Infectious Disease, Binzhou Medical University Hospital, Binzhou, China.
Minim Invasive Ther Allied Technol. 2021 Dec;30(6):356-362. doi: 10.1080/13645706.2020.1735446. Epub 2020 Mar 3.
This study aimed to assess clinical efficacy and long-term patient outcomes in individuals with malignant hilar biliary obstruction (MHBO) that had been treated insertion of a stent with a radioactive seed strand (RSS).
A total of 84 MHBO patients were treated either normal stent insertion ( = 48) or stent with RSS insertion ( = 36) from January 2015 to December 2018.
The technical success rates of normal stent insertion and stent with RSS insertion were 93.8% (45/48) and 97.2% (35/36), respectively ( = .632), with clinical success rates of 93.3% (42/45) and 100% (35/35), respectively ( = .252). In these two patient groups, 11 and seven patients, respectively, suffered from stent dysfunction ( = .637). In the normal and RSS groups, median stent patency was 165 and 225 days, respectively ( < .001). All patients in the present study died due to tumor progression, with median survival times of 188 and 250 days in the normal and RSS stent groups, respectively ( < .001).
Relative to normal stent insertion, combined stent with RSS insertion can effectively prolong both stent patency and patient survival in patients with MHBO.
本研究旨在评估恶性肝门胆管梗阻（MHBO）患者接受支架内放射性种子丝（RSS）置入治疗的临床疗效和长期患者结局。
2015 年 1 月至 2018 年 12 月，共 84 例 MHBO 患者接受了普通支架置入（ = 48 例）或支架内 RSS 置入（ = 36 例）。
普通支架置入和支架内 RSS 置入的技术成功率分别为 93.8%（45/48）和 97.2%（35/36）（ = .632），临床成功率分别为 93.3%（42/45）和 100%（35/35）（ = .252）。在这两组患者中，分别有 11 例和 7 例患者发生支架功能障碍（ = .637）。在普通支架组和 RSS 支架组中，中位支架通畅时间分别为 165 和 225 天（ < .001）。本研究所有患者均因肿瘤进展而死亡，普通支架组和 RSS 支架组的中位生存时间分别为 188 和 250 天（ < .001）。
与普通支架置入相比，RSS 联合支架置入可有效延长 MHBO 患者的支架通畅时间和患者生存时间。
