Kocot A
Klinik und Poliklinik für Urologie und Kinderurologie, Julius Maximilians Universität Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
Urologe A. 2020 Apr;59(4):408-415. doi: 10.1007/s00120-020-01153-5.
The combination of a severe urethral sphincter defect with simultaneous development of recurrent bladder outlet obstruction characterizes a "devastated bladder outlet", which often is not surgically reconstructable. Clinically, quality of life is considerably compromised in affected patients with a wide variance of symptoms, mostly complete incontinence, but also urinary retention. This condition is usually preceded by multiple endoscopic interventions or even open surgical procedures, occasionally also in combination with radiotherapy of the pelvic region as part of multimodal oncological therapy. Treatment of these cases is complex and limited to few promising procedures. A potential therapy should primarily include the decision about the possibility of preserving the urinary bladder. In individual cases, this can result in simple therapy options while at the same time maintaining an acceptable quality of life for those affected. If there is no possibility of a refunctionalization of the original bladder, supravesical urinary diversion is indicated as a last-resort therapy. This paper provides a review as well as the limits and possibilities of conservative and surgical treatment options for a devastated bladder outlet.
严重尿道括约肌缺损并同时出现复发性膀胱出口梗阻的情况被称为“膀胱出口毁损”,这种情况通常无法通过手术重建。临床上,受影响患者的生活质量会受到严重影响,症状差异很大,主要是完全失禁,也有尿潴留。这种情况通常在多次内镜干预甚至开放手术之前出现,偶尔也会作为多模式肿瘤治疗的一部分联合盆腔放疗。这些病例的治疗很复杂且限于少数有前景的手术。潜在的治疗应首先包括决定保留膀胱的可能性。在个别情况下,这可能导致简单的治疗选择,同时为受影响者维持可接受的生活质量。如果原膀胱无法恢复功能,则应采用膀胱上尿路改道作为最后的治疗手段。本文综述了膀胱出口毁损的保守和手术治疗选择的局限性及可能性。