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优化半精制卡拉胶(SRC)和葡甘露聚糖浓度作为凝胶剂对干玉米芯提取物(L.)防晒凝胶物理稳定性的影响

Optimization of SRC (Semi Refined Carrageenan) and Glucomannan Concentration as Gelling Agent to the Physical Stability Sunscreen Gel of Dry Corncob Extract ( L.).

作者信息

Yati Kori, Srifiana Yudi, Lestari Asri Indah

机构信息

Department of Pharmacy, Faculty Pharmacy and Sains, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia.

出版信息

Open Access Maced J Med Sci. 2019 Nov 14;7(22):3833-3836. doi: 10.3889/oamjms.2019.514. eCollection 2019 Nov 30.

Abstract

BACKGROUND

Corncob is one of crude drug which containing phenolic compounds that can be used as an active ingredient for sunscreen preparations. In this study, extracts of dried corn cob made into a gel formulation using SRC (Semi Refined Carrageenan) and glucomannan as a gelling agent.

AIM

This study aims to determine the optimal concentration of SRC (Semi Refined Carrageenan) and glucomannan to the physical stability of the gel.

METHODS

Gel made into four formulas with a ratio of 1: 4 and the concentration of each formula was 1%, 1.5%, 2%, 2.5%. Each formula was evaluated for 6 weeks of storage that includes organoleptic test, homogeneity, pH, viscosity, dispersive power, freeze-thaw test and centrifugation.

RESULTS

The results showed the fourth formula did not change the organoleptic test and homogeneity test. In the test separation of the freeze-thaw method, the fourth formula was stable, while in the centrifugation test formula 1 and 2 was been separation. pH and viscosity results obtained from statistics with a two-way ANOVA showed significant differences in each formula.

CONCLUSION

From the results of this study concluded that the formula 3 with a concentration of 2% was the optimal concentration as a gelling agent.

摘要

背景

玉米芯是一种含有酚类化合物的粗药材,这些酚类化合物可作为防晒制剂的活性成分。在本研究中,将干燥玉米芯提取物制成凝胶制剂,使用半精制卡拉胶(SRC)和葡甘露聚糖作为胶凝剂。

目的

本研究旨在确定半精制卡拉胶(SRC)和葡甘露聚糖的最佳浓度对凝胶物理稳定性的影响。

方法

将凝胶制成四种配方,比例为1:4,每种配方的浓度分别为1%、1.5%、2%、2.5%。对每个配方进行6周的储存评估,包括感官测试、均匀性、pH值、粘度、分散力、冻融试验和离心试验。

结果

结果表明,第四种配方在感官测试和均匀性测试中没有变化。在冻融法的分离测试中,第四种配方是稳定的,而在离心测试中,配方1和2出现了分离。通过双向方差分析获得的pH值和粘度结果表明,每个配方之间存在显著差异。

结论

从本研究结果得出,浓度为2%的配方3是作为胶凝剂的最佳浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac81/7048369/713a87695dac/OAMJMS-7-3833-g001.jpg

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