Prasetyo Bayu Eko, Rafika Dwi, Laila Lia, Aminah Fat
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia.
Nanomedicine Center of Innovation, Universitas Sumatera Utara, Medan, 20155, Indonesia.
Open Access Maced J Med Sci. 2019 Nov 14;7(22):3907-3910. doi: 10.3889/oamjms.2019.531. eCollection 2019 Nov 30.
The product development of an anti-aging dosage for human skin is a very interesting issue because every human wants to be looked young as long as possible. A studies and development of plant that contain of antioxidant properties need to be studied further.
The aim of this research was to formulate and evaluate the physical and anti-aging effect of the Peel-Off Gel Mask from Red Bean Ethanol Extract (PGMRB).
The Extract Ethanol of Red Bean was extracted by maceration methods with ethanol 96%. The Peel-off base was consisted of Polyvinyl alcohol, glycerin and carbomer 940. The gel formulation was made in 3 formulas (F1, F2, and F3) consisted with 1%, 3% and 5% ethanol extract, respectively. The blank formula (F0) was also prepared as a control formula. The evaluation of gel formulation included organoleptic test, pH determination, stability test, homogeneity test, peeling time, irritation test and anti-aging effect test included moisture level, skin pore size, the evenness test and dark spot test by using skin analyzer.
All of the formula showed a homogen, pH around 6, peeling time less than 20 minutes, no irritation and stable for 12 weeks storage at room temperature. The treatment with PGMRB demonstrated an improvement on the moisture level, pore size, evenness and the number of black spots with F3 containing 5% extract as the best formula.
The ethanol extract of red bean can be formulated become a peel-off gel mask and having the anti-aging effect.
开发用于人类皮肤的抗衰老制剂是一个非常有趣的课题，因为每个人都希望尽可能长久地保持年轻容颜。对具有抗氧化特性的植物进行研究和开发仍需进一步深入。
本研究旨在制备并评估红豆乙醇提取物剥离凝胶面膜（PGMRB）的物理性质和抗衰老效果。
采用浸渍法，用96%乙醇提取红豆乙醇提取物。剥离基质由聚乙烯醇、甘油和卡波姆940组成。凝胶制剂制成3种配方（F1、F2和F3），分别含有1%、3%和5%的乙醇提取物。还制备了空白配方（F0）作为对照配方。凝胶制剂的评估包括感官测试、pH值测定、稳定性测试、均匀性测试、剥离时间、刺激性测试以及抗衰老效果测试，其中抗衰老效果测试使用皮肤分析仪进行水分含量、皮肤毛孔大小、平整度测试和黑斑测试。
所有配方均表现出均匀性，pH值约为6，剥离时间少于20分钟，无刺激性，在室温下储存12周稳定。PGMRB处理显示出在水分含量、毛孔大小、平整度和黑斑数量方面有所改善，含5%提取物的F3配方为最佳配方。
红豆乙醇提取物可制成剥离凝胶面膜并具有抗衰老效果。
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