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胸腺瘤相关纯红细胞再生障碍的管理：血液替代品HBOC-201在一名耶和华见证会信徒中的新用途。

Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness.

作者信息

Rubinstein Maria M, Goss Cheryl, Avecilla Scott T, Dubé Gregory P, Riely Gregory J, Mones Jodi V

机构信息

Department of Medicine Memorial Sloan Kettering Cancer Center New York New York.

Department of Laboratory Medicine Memorial Sloan Kettering Cancer Center New York New York.

出版信息

Clin Case Rep. 2019 Dec 26;8(2):289-292. doi: 10.1002/ccr3.2626. eCollection 2020 Feb.

DOI:10.1002/ccr3.2626
PMID:32128175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7044386/
Abstract

Pure red cell aplasia (PRCA) is a rare paraneoplastic syndrome occasionally associated with thymomas. Here, we report on the first ever use of a bovine hemoglobin-based oxygen carrier, HBOC-201 (HbO2 Therapeutics LLC; Hemopure, Waltham, MA) for the supportive management of pure red cell aplasia in a Jehovah Witness patient.

摘要

纯红细胞再生障碍性贫血（PRCA）是一种罕见的副肿瘤综合征，偶尔与胸腺瘤相关。在此，我们报告了首例在一名耶和华见证会患者中使用基于牛血红蛋白的氧载体HBOC-201（HbO2 Therapeutics LLC；Hemopure，马萨诸塞州沃尔瑟姆）对纯红细胞再生障碍性贫血进行支持性治疗的病例。

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本文引用的文献

1
Analytical interference of HBOC-201 (Hemopure, a synthetic hemoglobin-based oxygen carrier) on four common clinical chemistry platforms.HBOC-201（Hemopure，一种合成血红蛋白基氧载体）对四种常见临床化学平台的分析干扰。
Clin Chim Acta. 2018 Jul;482:33-39. doi: 10.1016/j.cca.2018.03.017. Epub 2018 Mar 23.
2
Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients.HBOC-201 临床试验、扩大准入和临床应用中 1701 例患者的陷阱和经验教训用户指南。
Shock. 2019 Oct;52(1S Suppl 1):92-99. doi: 10.1097/SHK.0000000000001038.
3
How do we treat life-threatening anemia in a Jehovah's Witness patient?我们如何治疗耶和华见证会患者的危及生命的贫血？
Transfusion. 2014 Dec;54(12):3026-34. doi: 10.1111/trf.12888. Epub 2014 Oct 21.
4
HBOC-201: the multi-purpose oxygen therapeutic.HBOC - 201：多功能氧疗剂。
EuroIntervention. 2008 May;4(1):161-5. doi: 10.4244/eijv4i1a26.
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Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group.胸腺瘤相关纯红细胞再生障碍性贫血免疫抑制治疗后的长期反应及结局：日本PRCA协作研究组的一项全国性队列研究
Haematologica. 2008 Jan;93(1):27-33. doi: 10.3324/haematol.11655.
6
Pure red cell aplasia associated with thymoma: clinical insights from a 50-year single-institution experience.胸腺瘤相关的纯红细胞再生障碍：来自一家机构50年经验的临床见解
Br J Haematol. 2006 Nov;135(3):405-7. doi: 10.1111/j.1365-2141.2006.06295.x.