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精准医疗：一个指导多药相互作用和药物基因组学临床应用的说明性病例系列

Precision medication: An illustrative case series guiding the clinical application of multi-drug interactions and pharmacogenomics.

作者信息

Bain Kevin T, McGain David, Cicali Emily J, Knowlton Calvin H, Michaud Veronique, Turgeon Jacques

机构信息

Tabula Rasa HealthCare Moorestown NJ USA.

Department of Pharmacy University of the Sciences Philadelphia PA USA.

出版信息

Clin Case Rep. 2019 Dec 23;8(2):305-312. doi: 10.1002/ccr3.2604. eCollection 2020 Feb.

DOI:10.1002/ccr3.2604
PMID:32128178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7044418/
Abstract

Precision medication entails selecting the precise medication, dose, and timing of administration. Multi-drug interactions and genetics significantly affect precision medication. In this article, we present two simulated cases for real-world applications of precision medication. Clinicians may need to acquire additional skills to apply the principles illustrated by these cases.

摘要

精准用药需要选择精确的药物、剂量和给药时间。多种药物相互作用和遗传学对精准用药有显著影响。在本文中，我们展示了两个精准用药实际应用的模拟案例。临床医生可能需要获得额外的技能来应用这些案例所阐述的原则。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/37f76ce59a94/CCR3-8-305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/759f276d2b4c/CCR3-8-305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/d013473ca796/CCR3-8-305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/9bf1714ba1c3/CCR3-8-305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/37f76ce59a94/CCR3-8-305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/759f276d2b4c/CCR3-8-305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/d013473ca796/CCR3-8-305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/9bf1714ba1c3/CCR3-8-305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8814/7044418/37f76ce59a94/CCR3-8-305-g004.jpg

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Clin Pharmacol Ther. 2017 Sep;102(3):397-404. doi: 10.1002/cpt.668. Epub 2017 Apr 4.
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Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients.奥美拉唑、泮托拉唑及CYP2C19对稳定型冠状动脉疾病患者氯吡格雷药代动力学-药效学关系的影响。
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阿片类药物、多药合用与药物相互作用：需要技术范式转变来缓解持续的阿片类药物流行。
Pharmacy (Basel). 2020 Aug 25;8(3):154. doi: 10.3390/pharmacy8030154.
Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.
乳腺癌耐药蛋白（ABCG2）在临床药代动力学及药物相互作用中的研究：关于临床“受害者”和“肇事者”药物相互作用研究设计的实用建议
Drug Metab Dispos. 2015 Apr;43(4):490-509. doi: 10.1124/dmd.114.062174. Epub 2015 Jan 13.
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Evaluation of the relationship between polymorphisms in CYP2C19 and the pharmacokinetics of omeprazole, pantoprazole and rabeprazole.CYP2C19基因多态性与奥美拉唑、泮托拉唑和雷贝拉唑药代动力学之间关系的评估。
Pharmacogenomics. 2014;15(15):1893-901. doi: 10.2217/pgs.14.141.
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